西格列汀联合二甲双胍治疗老年2型糖尿病45例  

Sitagliptin Combined with Metformin for Treating Elderly Type 2 Diabetes Mellitus in 45 Cases

作　　者：王少蓉[1] 刘文莉[1] 帖丽丽[1] 

机构地区：[1]陕西省第二人民医院,陕西西安710005

出　　处：《中国药业》2015年第19期91-93,共3页China Pharmaceuticals

摘　　要：目的探讨西格列汀联合二甲双胍治疗老年2型糖尿病(T2DM)的临床疗效及安全性。方法选取2014年1月至2015年1月收治的老年T2DM患者90例,随机分为观察组和对照组,各45例,两组患者均予饮食、运动等生活方式干预,并根据病情应用控制血压、血脂药物,对照组给予盐酸二甲双胍,观察组在对照组基础上联用西格列汀,均连续用药3个月为1个疗程。结果治疗后,两组患者体重指数(BMI)较治疗前无明显变化(P>0.05),血糖参数[空腹血糖(FPG)、餐后两小时血糖(2 h PG)、糖化血红蛋白(Hb A1C)]较治疗前均有下降,与对照组相比,观察组血糖参数改善更显著(P<0.05)。与治疗前比较,两组患者胰岛素敏感指数(HOMA-IS)、胰岛β细胞功能(HOMA-β)均显著升高,且观察组改善较对照组更明显(P<0.05)。治疗过程中,两组患者肝、肾功能均未出现异常,不良反应均较轻微,发生率无统计学差异(P>0.05)。结论西格列汀联合二甲双胍治疗老年T2DM较单用二甲双胍治疗能更有效地控制血糖,提高胰岛素敏感性,保护β细胞功能,降低不良反应的发生率,具有临床推广意义。Objective To investigate the clinical efficacy and safety of sitagliptin combined with metformin in treating type 2 diabetes mellitus （T2DM）. Methods 90 cases of patient during Jan 2014 to Jan 2015 were randomly divided into the control group and the observation group, 45 cases in each group. The two groups were given life style intervention such as diet and exercise, and the application of hypertension drugs and hypolipidemic drugs according to the conditions. The control group was given metformin hydrochloride; on the basis of the control group, the observation group was given sitagliptin. Two groups of patients were treated for 3 months for 1 course of treatment. Results After treatment, the BMI index in two groups had no significant improvement（ P 〉 0. 05）. Compared with those before treatment, the blood parameters of FPG, 2 hPG, HbAlc of the two groups decreased, and the decrease in the observation group was more significant（ P 〈 0. 05）. Compared with before treatment, the HOMA- IS and HOMA- beta of the two groups were significantly increased（ P 〈 0. 05）, and the increase in the observation group was more significant. The liver and renal function were normal in the two groups, and the adverse reactions of the two groups were mild with no significant difference between the two groups（ P 〉 0. 05）. Conclusion Compared with applying only metformin, sitagliptin combined with metformin in treating elderly type 2 diabetes mellitus can more effectively control blood sugar, improve insulin sensitivity, protect the beta cell function, reduce the incidence of adverse reactions and is worthy of clinical promotion.

关 键 词：西格列汀 二甲双胍 老年 2型糖尿病 

分 类 号：R969.4[医药卫生—药理学] R977.15[医药卫生—药学]