乳酸依沙吖啶溶液对糖尿病坏疽创面愈合的影响及护理  

Influence and Nursing Points of Lactate Ethacridine Solution in Healing Diabetic Gangrene Wound

作　　者：刘燕平[1] 

机构地区：[1]中国康复研究中心北京博爱医院,北京100068

出　　处：《中国药业》2015年第19期126-127,共2页China Pharmaceuticals

摘　　要：目的观察乳酸依沙吖啶溶液对糖尿病坏疽创面愈合的影响,并总结护理体会。方法选取2012年8月至2014年6月收治的糖尿病坏疽患者90例,随机分为对照组和观察组,各45例。两组患者在给予胰岛素控制血糖达标和其他相关治疗后,给予改善局部循环、营养支持的药物,并用抗生素控制感染,每日为坏疽创面彻底清创,辅以红外线照射,观察组在此基础上加用乳酸依沙吖啶溶液冲洗治疗,两组患者均每日换药1次,连续治疗4周。结果观察组总有效率为95.56%,高于对照组的88.89%(P<0.05);治疗后,观察组坏疽疮面脱腐率、肉芽占有率、炎性浸润消失率、渗出减少率、创面缩小率均优于对照组(P<0.05);治疗后,两组患者踝肱比、趾肱比指数均较治疗前有所增加,且观察组好于对照组(P<0.05);两组患者不良反应均较轻,发生率差异无统计学意义(P>0.05)。结论加用乳酸依沙吖啶溶液治疗糖尿病坏疽,临床疗效显著,可有效改善患者创面愈合情况,且无明显不良反应发生。配合适当的护理方案,能进一步提高疗效,值得临床推广。Objective To observe the influence and nursing points of Lactate Ethacridine Solution in healing diabetic gangrene wound. Methods 90 cases of diabetic gangrene patients from August 2012 to June 2014 were randomly divided into control group and observation group, 45 cases in each group. The two groups o were given treatment to improve local circulation, nutritional support drugs, antibiotics to control infection, daily gangrene wound debridement combined with infrared radiation after administration of insulin to control blood glucose and other related treatment, on this basis the observation group was given Lactate Ethacridine Solution. The two groups were dressing for 1 time 1 d in continuous treatment for 4 weeks. The clinical efficacy, as well as the treatment of gangrenous wound around the affected ankle brachial, toe-braehial ratio were observed after treatment. The adverse reactions in the two groups were recorded. Results The total effective rate of the observation group was 95.56%, which was higher than 88.89% of the control group （P 〈 0. 05）. After treatment, the corrosion rate, inflammatory infiltrates rate, decrement wound granulation shrink rate of the observation group were superior to control group（ P 〈 0. 05）; the ankle toe brachial index of the two groups were increased compared with before treatment, and the observation group was better than that of the control group（P 〈 0.05） . The incidence of adverse reactions in two groups were mild and with no statistically significant difference（ P 〉 0. 05）. Conclusion The Lactate Ethaefidine Solution in treating patients with diabetes mellitus gangrene has significant clinical effect, can effectively improve wound healing with no significant adverse reactions. Combined with appropriate care program, it can increase outcomes, and is worthy of promotion.

关 键 词：乳酸依沙吖啶溶液 糖尿病坏疽 创面愈合 护理 

分 类 号：R969.4[医药卫生—药理学] R979.7[医药卫生—药学]