血流感染病原体的分布及耐药性分析  

Bacterial distribution and drug resistance in bloodstream infections

作　　者：张哲庆[1] 金春梅[1] 

机构地区：[1]延边大学附属医院检验科,吉林延吉133000

出　　处：《现代预防医学》2015年第19期3624-3625,3628,共3页Modern Preventive Medicine

摘　　要：目的了解我院血流感染病原体的分布及其耐药性情况,为临床合理使用抗菌药物提供科学依据。方法采用BDBACTEC 9120全自动血培养仪对我院2010年1月至2013年12月收集的血液标本进行培养,用BD phonix-100对分离菌株进行鉴定和药敏试验,检测结果用WHONET5.6软件进行统计分析。结果共分离出377株细菌,革兰阴性菌202株,占53.6%,其中主要是大肠埃希菌106株(28.1%),肺炎克雷伯菌39株(10.3%);革兰阳性菌175株,占46.4%,其中凝固酶阴性葡萄球菌103株(27.3%),金黄色葡萄球菌33株(8.8%);未发现对万古霉素耐药的金黄色葡萄球菌分离株,也未检出对亚胺培南和美罗培南耐药的大肠埃希菌和肺炎克雷伯菌。结论血流感染的病原体以革兰阴性菌为主,耐药性普遍,临床应根据药敏试验结果合理选择抗菌药物。Objective To get information about bacterial distribution and resistance in bloodstream infection. Methods Various clinical department blood cultures samples were eollected from 2010 January to 2013 December in Yanbian hospital by BD Bactee9120. The identification and antimicrobial suseeptibility testing were performed with phonix-100. Statistical analysis was done with WHONET 5.6. Results A total of 377 bacterial strains were isolated, and gram negative bacteria accounted for 53.6%, of which Escherichia eoli accounted for 28.1%, followed by Klebsiella pneumonia 10.3%, gram positive bacteria 46.4%, of which Coagulase negative Staphylococcus accounted for 27.3%. No vancomycin resistant Staphylococcus aureus were found. No imipenem and meropenem resistant Escherichia eoli and Klebsiella pneumonia were found. Conclusion Gram negative bacteria were main pathogeninc bacterium of blood stream infection. Bacterial resistance was common, and sthe clinician should rationally use the antibiotics according to the result of antimicrobial susceptibility test.

关 键 词：血流感染 耐药性 血培养 

分 类 号：R117[医药卫生—公共卫生与预防医学]