蛋白质折叠调控策略的研究进展  

Recent Progress in Regulation Strategy of Protein Folding

作　　者：黄帆[1,2] 曲敖廷 王建祖[2] 安英丽[2] 史林启[2] 

机构地区：[1]北京协和医学院&中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192 [2]功能高分子材料教育部重点实验室,南开大学高分子化学研究所,天津化学化工协同创新中心,药物化学生物学国家重点实验室,天津300071

出　　处：《高分子通报》2015年第9期71-86,共16页Polymer Bulletin

基　　金：国家自然科学基金(91127045;51390483);973计划(2011CB932503)资助项目

摘　　要：蛋白质作为生命的物质基础,只有通过正确地折叠和组装,形成精确的三维空间结构,才能保持生理活性,并在生命体中发挥其正常的生物学功能。一旦蛋白质发生错误折叠和异常的聚集,不仅会丧失其生物活性,还会导致阿尔兹海默症、帕金森症、亨廷顿氏舞蹈症等神经退行性疾病以及某些癌症,对人类的生命健康构成了严重的威胁。因此,如何有效地调控蛋白质折叠已成为生命科学研究中最具有挑战性的课题之一。本文在简单介绍蛋白质折叠机制的基础上,综述了近年来蛋白质折叠调控策略的研究进展,着重讨论了基于纳米材料的调控方法,并评述了该领域研究的发展趋势和方向。Proteins, as the material basis of life, must fold and assembled property into precise three-dimensional conformations to maintain their physiological activity, and to fulfill their normal biological functions. Once misfolding and abnormal aggregation, proteins will not only lose their biological activity, but also lead to a number of serious diseases, such as Alzheimer＇s disease, Parkinson＇s disease, Huntington＇s disease and some types of cancers, which are terrible threaten to human life and health. Therefore, how to effectively regulate protein folding has become one of the most challenging problems in life sciences. On the basis of a brief introduction of protein folding mechanism, we reviewed the recent progress in the development of protein folding control strategy, discussed the methods based on nanomaterials in detail and finally proposed the development trend of this field.

关 键 词：蛋白质折叠 蛋白质聚集 分子伴侣 纳米材料 

分 类 号：O629.73[理学—有机化学]