2709例泌尿生殖道支原体培养及耐药性分析  

Analysis of drug resistance and cultivation of ureaplasma urealyticum and mycoplasma hominis from 2709 cases with urogenital infection

作　　者：张扬丽[1] 蒋明栋[1] 王智华[1] 李静梅[1] 

机构地区：[1]中国人民解放军第92医院检验科,福建南平353000

出　　处：《微生物学免疫学进展》2015年第5期45-48,共4页Progress In Microbiology and Immunology

摘　　要：目的：对门诊2709例病例的支原体培养标本进行泌尿生殖道解脲脲原体（ Ureaplasma urealyticum ，Uu）与人型支原体（ Mycoplasma hominis，Mh）感染情况及耐药性的分析，为临床的诊断及治疗提供参考依据。方法采用商品化试剂盒对2709例标本进行Uu、Mh半定量培养及药物敏感试验。结果2709例标本中总阳性率为56．15％，其中Uu占比39．87％、Mh占比8．08％、Uu和Mh共同阳性者占比8．19％，男性标本阳性率为47．78％、女性标本阳性率为66．26％。药敏结果显示，单独Uu感染者对喹诺酮类（5．00％～34．40％）、红霉素（42．80％）敏感率较低，而对四环素类（88．90％～95．00％）、交沙霉素（97．30％）敏感率较高。单独Mh感染者与Uu和Mh混合感染者耐药情况均较为严重，除四环素、强力霉素、交沙霉素、美满霉素敏感率在50％以上，对其余药物的敏感率均在50％以下。结论泌尿生殖道支原体感染以Uu感染为主，其中女性感染率高于男性；药敏结果显示感染者对四环素、强力霉素、交沙霉素、美满霉素敏感率较高，单独Mh感染者与Uu和Mh混合感染者耐药情况更为严重。Objective To investigate the infection status and the drug resistance of cultured ureaplasma urealyticum （ Uu） and mycoplasma hominis（ Mh） in samples collected from out-patients and to provide a basic reference evidence in diagnosis and treatment.Methods A total of 2 709 Un and Mh samples were tested with the commercial kits.Results The posi-tive rate was 56.15%, the positive rates for Uu and MH were 39.87% and 8.08% separately, and both positive for Un and Mh mixed infection was 8.19%in the total samples.The positive rate in male and femaie sample were 47.78% and 66.26%, respectively.The tested result showed that Uu patients had a low drug sensitivity to quinolones （ 5.00%-34.40%） and roxithromycin（42.80%）.but a high drug sensitivity to tetracycline （88.90%-95.00%） and josamycin （97.30%）and the patients who were infected by Mh alone or co-infected by Uu and Mh had a high resistance to these drugs, the sensitivity was more than 50% for tetracycline, doxycycline, josamycin and minocycline, and was less than 50%for the other drugs.Conclusion Uu infection was predominance in the urogential infection, which was higher in fe-male than that in male.The drug sensitivity test result showed that these patients had a high sensitivity to tetracycline, dox-ycycline, josamycin and minocycline, and for the patients with Mh infection alone and the mixed infection for Uu and Mh. the drug resistance was even worse.

关 键 词：解脲脲原体 人型支原体 混合感染 药敏试验 半定量计数 

分 类 号：R446.5[医药卫生—诊断学]