环形电切术治疗宫颈上皮内瘤样病变后人乳头瘤病毒持续感染的临床分析  

Clinical Analysis of Loop Electrosurgical Excision Procedure Treating Persistent HPV Infection after Cervical Intraepithelial Neoplasia Treatment

作　　者：李江宁[1] 刁海丹[1] 

机构地区：[1]大连市第三人民医院妇科,辽宁大连116033

出　　处：《医学综述》2015年第18期3454-3456,共3页Medical Recapitulate

摘　　要：目的探讨环形电切术治疗宫颈上皮内瘤样病变(CIN)后人乳头瘤病毒(HPV)持续感染临床效果。方法选取2011年2月至2013年2月大连市第三人民医院妇科收治的70例CIN后HPV持续感染患者为研究对象,采用随机数字表法分成两组,每组35例,对照组予以冷刀宫颈锥切术治疗,观察组用环形电切术治疗,观察两组治疗后临床效果。结果对照组手术残留率、治愈率、感染持续率和复发率分别为14.3%、68.5%、11.4%、14.3%;观察组手术残留率、治愈率、感染持续率和复发率分别为11.4%、80.0%、8.6%、11.4%,两组比较差异无统计学意义(P>0.05);而在术中出血量、手术时间、切口愈合时间、术后出血量、住院时间、HPV转阴时间和并发症发生率的比较,差异有统计学意义(P<0.05)。结论环形电切术不仅能切除高级CIN,且能清除高危型HPV持续感染,临床效果显著。Objective To investigate the clinical effect of loop electrosurgical excision procedure treating persistent human papilloma virus（ HPV） infection after cervical intraepithelial neoplasia（ CIN） treatment. Methods From Feb. 2011 to Feb. 2013,in Dalian Third People＇ s Hospital,70 cases of persistent CIN HPV infection were included in the study,and divided into two groups according to random number-table method,35 cases in each group： the control group received cold-knife conization treatment,the observation group received loop electrosurgical excision procedure,and the clinical effect of the two groups was observed after treatment. Results The postoperative residual rate,the cure rate,relapse rate and sustained infection rate of the control group were 14. 3%,68. 5%,11. 4%,14. 3%; of the observation group were 11. 4%,80. 0%,8. 6%,11. 4% respectively,no significant differences between the two groups（ P 〈0. 05）; while the blood loss,operative time,wound healing time,postoperative blood loss,hospital stay,HPV turning negative time and complication incidence of the two groups had statistically significant difference（ P 〈0. 05）.Conclusion Loop electrosurgical excision procedure not only can cut advanced CIN,but also can remove persistent high-risk HPV infection,with significant clinical effect.

关 键 词：宫颈上皮内瘤样病变 环形电切术 人乳头瘤病毒 持续感染 临床效果 

分 类 号：R452[医药卫生—治疗学]