小剂量沙利度胺治疗老年性瘙痒症的临床观察  

Clinical observation of low dose thalidomide therapy in elderly patients with senile pruritus

作　　者：畅晓元[1] 李上云[1] 刘岩[1] 

机构地区：[1]沈阳市第七人民医院皮肤科,沈阳110003

出　　处：《实用药物与临床》2015年第9期1052-1055,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的研究口服小剂量沙利度胺治疗老年性瘙痒症的疗效。方法将75例老年性瘙痒症患者随机分为2组。治疗组口服沙利度胺75 mg,每晚1次;对照组口服盐酸左西替利嗪片5 mg,每晚1次。分别于治疗前、治疗4周时进行瘙痒评分,治疗后观察两组疗效及安全性。结果治疗组和对照组治疗前瘙痒评分分别为8.36±2.89、8.24±2.32,差异无统计学意义(P>0.05),治疗后治疗组瘙痒评分低于照组(3.71±1.92vs.5.45±2.11),差异有统计学意义(t=3.74,P<0.01),治疗组总有效率为86.8%,对照组为43.2%,治疗组明显优于对照组(χ2=15.73,P<0.01)。结论应用小剂量沙利度胺治疗老年性瘙痒症的疗效良好,值得进一步研究及推广应用。Objective To study the efficacy of oral low dose thalidomide in the treatment of senile pruri-tus. Methods 75 patients with senile pruritus were randomly divided into two groups. Patients in treatment group took 75 mg of thalidomide every night,while patients in control group took 5 mg of levocetirizine hydrochloride tablets every night. Score of itching was assessed before and after 4-week treatment. Efficacy and safety were evaluated after treat-ment. Results Itching score of treatment group and control group before receiving treatment was 8. 36 ± 2. 89 and 8. 24 ±2. 32,there was no significant difference between the two groups （P〉0.05）. Itching score of treatment group was lower than that of control group （3. 71 ± 1. 92 vs. 5. 45 ± 2. 11）,there was significant difference between the two groups（t=3. 74,P〈0.01）. The overall response rate of treatment group was significantly higher than that of control group （86. 8% vs. 43. 2%,χ2 =15. 73,P〈0.01）. Conclusion Low dose thalidomide has a promising therapy effect in the treatment of senile pruritus. It is worthy of further studies and applications in clinic.

关 键 词：沙利度胺 老年性瘙痒症 小剂量 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]