泛素-蛋白酶体抑制剂对血管平滑肌细胞凋亡的影响  

Effects of ubiquitin-proteasome inhibitor on apoptosis of vascular smooth muscle cells

作　　者：罗秀军[1] 孙瑞红[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《实用药物与临床》2015年第9期1101-1104,共4页Practical Pharmacy and Clinical Remedies

基　　金：黑龙江省自然科学基金(H201306)

摘　　要：血管平滑肌细胞(Vascular smooth muscle,VSMC)是构成血管壁的重要成分。在动脉粥样硬化(Atherosclerosis,AS)病变中,VSMC在病理状态下凋亡失平衡引起血管重塑,导致动脉粥样硬化的发生。目前研究发现,细胞凋亡在动脉粥样硬化形成的发病和治疗中具有重要意义,而泛素-蛋白酶体抑制剂(The ubiquitinproteasome inhibitor,UPI)能够促进VSM C凋亡进而影响动脉粥样硬化。本文对泛素-蛋白酶体抑制剂影响VSM C凋亡的机制进行了综述。Vascular smooth muscle cells （ VSMC） are the important components of the vessel wall. The apop-tosis unbalance of VSMC can cause vascular remodeling under the pathological state in the pathology of atherosclero-sis. Studies indicate that cell apoptosis plays an important role in the pathogenesis and treatmentof atherosclerosis. The ubiquitin-proteasome inhibitor （ UPI） can promote the apoptosis of VSMC to affect atherosclerosis. This article reviews the mechanism of UPI in the apoptosisof VSMC.

关 键 词：泛素-蛋白酶体抑制剂 血管平滑肌细胞 凋亡 

分 类 号：R54[医药卫生—心血管疾病]