金属卟啉仿生催化氧化2-甲基喹啉合成喹啉-2-羧酸  

Synthesis of quinoline-2-carboxylic acid by oxidation of 2-methyl-quinoline with metalloporphyrins as biomimetic catalysts

作　　者：吴翠敏[1] 白金泉[1] 侯巍巍[1] 

机构地区：[1]北京工业大学环境与能源工程学院化学化工系,北京100124

出　　处：《应用化工》2015年第9期1617-1620,1626,共5页Applied Chemical Industry

基　　金：北京市自然科学基金课题(21005012200302)

摘　　要：研究了在温和的条件下,金属卟啉催化氧气氧化2-甲基喹啉为喹啉-2-羧酸的新的绿色合成方法。重点考察了金属卟啉种类及用量、反应温度和压力、反应时间、碱的浓度、溶剂种类等不同影响因素对反应的影响。结果表明,在最优的反应条件下(120℃,1.5 MPa,8 h,4×10-5mol/L的T(p-OCH3)PPCo Cl,1.6 mol/L的Na OH,溶剂为乙醇)2-甲基喹啉的转化率达到了40.75%,喹啉-2-羧酸的选择性和收率分别达到了24.59%和10.02%,并研究了该反应的机理。The novel green synthesis method of 2-methyl-quinoline to quinoline-2-carboxylic acid cata-lyzed by metalloporphyrins under mild conditions with molecular oxygen was reported. Different influen-cing factors including type and content of the catalyst,reaction temperature and pressure,reaction time, concentration of sodium hydroxide and solvent were investigated. The results showed under the optimal conditions：4. 0 × 10 -5 mol/L T（p-OCH3）PPCoCl,1. 6 mol/L NaOH and 1. 5 MPa of the oxygen pressure at 120 ℃ for 8 h ethanol as solvent,conversion rate of 2-methyl-quinoline reached 40. 75%,and the se-lectivity and the yield of quinoline-2-carboxylic acid reached 24. 59% and 10. 02%,respectively,and the reaction mechanism was studied.

关 键 词：喹啉-2-羧酸 金属卟啉 仿生催化 2-甲基喹啉 反应机理 

分 类 号：TQ016[化学工程] TQ031.7