磁性脂质体的制备及在肿瘤诊断与靶向治疗中的应用进展  

Progresses in preparation and application of magnetoliposomes in tumor diagnosis and tumor targeting therapy

作　　者：柴云[1] 许光宇[1,2] 翟翠萍[1] 郑林萍[2] 

机构地区：[1]河南大学化学化工学院精细化学与工程研究所,河南开封475004 [2]河南大学药学院,河南开封475004

出　　处：《化学研究》2015年第5期545-550,共6页Chemical Research

基　　金：河南省科技发展计划项目(122102210228)

摘　　要：磁性脂质体是近年来发展起来的新型靶向制剂,能在外加磁场作用下大量滞留在靶部位.由于磁性脂质体具有良好的生物相容性、无毒、易生物降解,因而被广泛用于肿瘤诊断与靶向治疗等领域.本文作者综述了磁性脂质体的制备方法及其在肿瘤诊断与靶向治疗中的应用进展.Magnetoliposomes ,a new class of targeting agents ,can be guided to the targeting site and accumulates in the human body ,and thus developed quickly recently .Due to its excel‐lent biocompatibility ,nontoxicity and favorable biodegradability ,magnetoliposomes has been extensively employed in tumor diagnosis and tumor targeting therapy .In this paper ,progresses in preparation and application of magnetoliposomes in tumor diagnosis and tumor targeting therapy have been review ed .

关 键 词：磁性脂质体 靶向治疗 肿瘤诊断 磁共振成像 

分 类 号：O614.81[理学—无机化学]