(羟基喜树碱@胆酸钠)-层状双金属氢氧化物纳米杂化物的组装及表征  

Fabrication and Characterization of(Hydroxyl camptothecin@sodium cholate)-layered Double Hydroxide Nanohybrids

作　　者：庞秀江[1] 刘源[1] 陈利[2] 全贞兰[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,生态化工国家重点实验室培育基地,青岛266042 [2]高分子科学与工程学院,橡塑材料与工程教育部重点实验室,青岛266042

出　　处：《高等学校化学学报》2015年第10期1933-1938,共6页Chemical Journal of Chinese Universities

基　　金：山东省自然科学基金联合专项(批准号:ZR2014BL005);青岛科技大学博士基金(批准号:0022610)资助~~

摘　　要：采用'药物修饰-共组装'法制备了(羟基喜树碱@胆酸钠)-层状双金属氢氧化物纳米杂化物.先用胆酸钠(SCL)包裹羟基喜树碱(HCPT)形成胶束,再与微反应器制备的层状双氢氧化物(LDH)纳米片共组装形成纳米杂化物,其载药量可达12.9%,杂化物中HCPT以高生物活性的内酯形式存在.采用聚乙二醇(PEG)和羧甲基纤维素(CMC)分别对所制备的(HCPT@SCL)-LDH纳米杂化物进行了表面修饰,结果表明,纳米杂化物的分散性得到明显改善;PEG的修饰效果优于CMC,所获得的PEG-(HCPT@SCL)-LDH杂化物的平均粒径可小至约70 nm,具有良好的分散性和药物缓释效果.其药物释放过程可用准二级动力学方程描述,颗粒内部扩散是药物释放过程的控制步骤.（ Hydroxyl camptothecin @ sodium cholate）-layered double hydroxide（ LDH） nanohybrids were prepared by a modified drug-coassembly method. Firstly,Hydroxyl camptothecin（ HCPT） was incorporated into micelles derived from sodium cholate（ SCL） which negatively charged. The negatively charged micelles intercalated HCPT@ SCL-LDH nanohybrids were prepared by a co-assembly between LDH nanosheets and sodium cholate micelles with the encapsulated HCPT could keep the biological active lactone form,and the drug loading of so-obtained nanohybrid was 12. 9%.（ HCPT @ SCL）-LDH was modified using polyethylene glycol（ PEG） and carboxymethylcellulose（ CMC）,respectively. The results showed that the dispersity of nanohybrids was obviously improved,and PEG worked better than CMC. The PEG-（ HCPT@ SCL）-LDH had favorable dispersity with average size of ca. 70 nm. PEG-（ HCPT@ SCL）-LDH showed well controlled release property and in vitro drug release kine-tics from the nanohybrids could be fitted with the pseudo-second-order kinetic model. The diffusion of HCPT through the LDH particles played an important role in controlling the drug release.

关 键 词：羟基喜树碱 层状双金属氢氧化物 共组装 纳米杂化物 

分 类 号：O641.1[理学—物理化学]