槟榔毒性机制的研究进展  

Research Progress of Toxicity Mechanism of Arecae Semen

作　　者：李习雄 胡冠英[1] 张三印[1] 

机构地区：[1]成都中医药大学基础医学院,成都611137

出　　处：《中国实验方剂学杂志》2015年第19期212-216,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81373969)

摘　　要：通过查阅近年来国内外槟榔相关研究文献,对槟榔的毒性机制进行分析、总结,为进一步研究槟榔的毒性机制提供参考。通过研究发现,咀嚼槟榔可导致口腔黏膜下纤维性变,对人和其他动物具有生殖系统毒性,可增加患肝硬化和肝细胞癌的风险,降低机体免疫系统功能,产生神经系统毒性,且能导致心血管、内分泌等疾病。近年来,槟榔的毒性作用引起国内、外众多学者的注意,且其毒性机制作用的研究取得了一定的进展,但其毒性详细机制至今尚未阐明。对近几年来槟榔毒性机制的研究作一综述,有利于对槟榔进行更科学、健康的开发利用。To analyze and summarize the toxicity mechanism of Arecae Semen based on related domestic and abroad literatures on Arecae Semen these years, and provide reference for the further study of Arecae Semen. Through research, we find that chewing Arecae Semen can lead to oral submucous fibrous changes. Meanwhile, it also can cause reproductive system toxicity for people and other animal, increase risk for cirrhosis and hepatocellular carcinoma, reduce the body＇s immune system function, produce nervous system toxicity and has a relationship with cardiovascular and endocrine disease. In recent years, the toxic effects of Arecae Semen have drawn much attention from many scholars at home and abroad, and the research of toxicity mechanism has achieved much progress. However, the detailed mechanism of toxicity has not been clarified so far. The summary of the researches on toxicity mechanism of Arecae Semen in recent years is conductive to more scientific and healthier development and utilization of Arecae Semen.

关 键 词：槟榔 毒性 机制 

分 类 号：R285.5[医药卫生—中药学]