脂联素基因单核苷酸多态性与妊娠期糖尿病的相关性评价  

Correlation assessment between adiponectin gene single nucleotide polymorphisms and gestational diabetes mellitus

作　　者：张展[1] 蒋陈东 冯杨[2] 张琳琳[2] 朱海[2] 刘慧[2] 宋婉玉 

机构地区：[1]商丘医学高等专科学校 [2]郑州大学第三附属医院检验科,河南郑州450052

出　　处：《中国妇幼保健》2015年第29期5083-5088,共6页Maternal and Child Health Care of China

基　　金：2014年度中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目〔2014FYH011〕

摘　　要：目的评价脂联素基因单核苷酸多态性rs22A1766（＋45T〉G）、rs1501299（＋276G〉T）及rs266729（-11377C〉G）与妊娠期糖尿病（GDM）的相关性。方法检索The HuGE Navigator．PubMed、EMbase、中国知网、万方数据库和维普科技期刊全文数据库中关于GDM的遗传关联性研究。检索时限均为各数据库建库起至2015年2月1日。严格制定纳入标准与剔除标准，并依此对文献进行筛选和数据提取，分别运用等位基因模型、显性基因模型及隐性基因模型3种遗传模型进行分析与对比评价。分析软件为RevMan5．3。结果共纳入8篇文献，其中中文文献5篇、英文文献3篇，共纳入783例GDM孕产妇和833例正常孕产妇。m2241766（＋45T〉G）评价显示，SNP（＋45T〉G）多态性与GDM发病风险无直接相关性，等位基因模型OR值为1．11，95％CI为0．76—1．62，P=0．6；显性基因模型OR值为1．05，95％CI为0．63～1．74，P=0．85；隐性基因模型OR值为1．28，95％CI为0．70～2．35，P=0．43。以中国人群进行亚组分析，中国人群SNP（＋45T〉G）多态性与GDM发病风险无直接相关性；等位基因模型OR值为0．95，95％（7／为0．53～1．71，P=0．88；显性基因模型OR值为0．89，95％CI为0．48—1．67，P=0．72；隐性基因模型OR值为1．13，95％CI为0．57～2．22，P：0．73。rs1501299（＋276G〉T）评价显示。SNP（＋276G〉T）多态性与GDM发病风险无直接相关性，等位基因模型OR值为0．95；95％CI为0．76～1．09，P=0．3；显性基因模型OR值为0．98，95％CI为0．68—1．42]，P=0．92；隐性基因模型OR值为0．96，95％CI为0．73～1．27，P=0．78；以中国人群进行亚组分析，中国人群SNP（＋276G〉T）多态性与GDM发病风险无直接相关性；等位基因模型OR值为0．97，95％CI为0．80—1．19，P=0．8。rs266729（-11377C〉G）评价显示，等位基因模型OR值为0．70，95％CI为0．52—0．95，Objective To evaluate the correlation between adiponectin gene single nucleotide polymorphisms rs2241766 （＋45 T〉G）, rs1501299 （＋276 G〉T）, rs266729 （-11377 C〉G） and gestational diabetes mellitus （GDM） . Methods Genetic relevant studies about GDM were searched in the HuGE Navigator, PubMed, EMbase, CNKI, Wanfang Database, and VIP Database. The retrieval time was from the establishment of the database to February 1, 2015. The inclusion criteria and exclusion criteria were strictly set to screen studies and abstract data. Allele model, dominant genetic model, and recessive genetic model were used for analysis and comparative evaluation. The data was analyzed on RevMan 5.3. Results A total of eight studies （783 GDM pregnant women and 833 normal pregnant women） were included, including five Chinese studies and three English studies, rs2241766 （＋45 T〉G） evaluation showed that there was no direct correlation between SNP （＋45 T〉G） polymorphism and risk of GDM; OR value of allele model was 1.11, 95%CI ranged from 0. 76 to 1.62, P = 0. 6 ; OR value of dominant genetic model was 1.05, 95% CI ranged from 0. 63 to 1.74, P = 0. 85 ; OR value of recessive genetic model was 1.28, 95% CI ranged from 0.70 to 2. 35, P = 0. 43. Taking Chinese population as a subgroup for analysis, there was no direct correlation between SNP （ ＋45 T〉G） polymorphism and risk of GDM; OR value of allele model was 0. 95, 95% CI ranged from 0. 53 to 1.71, P=0. 88 ; OR value of dominant genetic model was O. 89, 95% CI ranged from 0.48 to 1.67, P=0. 72 ; OR value of recessive genetic model was 1.13, 95% CI ranged from 0. 57 to 2. 22, P=0. 73. rs1501299 （ ＋276 G〉T） evaluation showed that there was no direct correla- tion between SNP （ ＋276 G〉T） polymorphism and risk of GDM ; OR value of allele model was 0. 95, 95% CI ranged from 0. 76 to 1.09, P= 0. 3 ; OR value of dominant genetic model was 0. 98, 95% CI ranged from 0. 68 to 1.42, P=0. 92 ; OR value of recessive genetic model was 0. 96, 95

关 键 词：脂联素基因 SNP 妊娠期糖尿病 META分析 

分 类 号：R714.256[医药卫生—妇产科学]