抗精神病药治疗老年期痴呆患者精神行为症状的心脑血管风险  

Cardiac-cerebral vascular side-effects of antipsychotics in elderly patients with behavioral and psychotic symptoms in dementia

作　　者：吴亦影[1] 施念玮[1] 倪秀石[1] 

机构地区：[1]上海交通大学附属第一人民医院老年科,上海200080

出　　处：《中国新药与临床杂志》2015年第9期661-665,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：痴呆的精神行为症状(BPSD)是老年期痴呆患者的常见症状,抗精神病药被广泛应用于老年人的BPSD治疗。但近年来关于抗精神病药导致的心脑血管风险引起临床医生的关注。本文就抗精神病药在老年人BPSD治疗中对脑血管、心血管、静脉栓塞、代谢等方面的不良反应作一综述,并探讨其产生的作用机制。Behavioral and psychotic symptoms in dementia （BPSD） are often apparent in aged patients affected with dementia. Antipsychotic agents have been widely used for BPSD. In recent years, the use of antipsychotic agents has been widely debated for reasons concerning their cardiaccerebral vascular adverse reactions. This paper reviewed cerebrovascular risk, cardiac effects, risk of venous thromboembolism and metabolic effects in treatment of BPSD with antipsychotic agents in aged patients, and discussed the underlying mechanisms.

关 键 词：老年人 抗精神病药 痴呆 心脑血管风险 药物不良反应 

分 类 号：R971.4[医药卫生—药品]