磁性Fe_3O_4纳米颗粒的制备及其在肿瘤治疗中的应用  

Preparation of magnetism Fe_3O_4 nanoparticles and its application in cancer therapy

作　　者：郭秀丽[1] 郑林萍[1] 张普玉[2] 

机构地区：[1]河南大学药学院,河南开封475004 [2]河南大学化学化工学院,河南开封475004

出　　处：《南阳师范学院学报》2015年第9期32-37,共6页Journal of Nanyang Normal University

基　　金：河南省教育厅科技研究重点项目(0001F01128)

摘　　要：综述了磁性Fe3O4纳米颗粒的制备方法.目前常用的方法有共沉淀法、水热法及溶剂热法、热分解法、微乳液法、溶胶-凝胶法等,讨论了这些方法的优缺点.介绍了磁性Fe3O4纳米粒子在靶向给药、靶向热疗及栓塞治疗中的应用,最后对磁性Fe3O4纳米粒子的研究前景进行了展望.This paper reviews the methods of preparation of magnetic Fe3O4 nanoparticles, in which the most commonly used ones are co-precipitation, hydrothermal method and solvothermal method, thermal decomposition method, microemulsion method, sol-gel method, and etc. Besides, the advantages and disadvantages of these methods are discussed as well. In addition, the paper introduces the application of magnetic Fe3O4 nanoparticles in the treatment of targeted drug delivery, targeting hyperthermia and embolization. Finally, the future develop- ment in the research of magnetic Fe3O4 nanoparticles is also prospected.

关 键 词：FE3O4 磁性 制备方法 肿瘤治疗 综述 

分 类 号：R932[医药卫生—生药学]