2例梅毒性心脏病的临床特点及治疗分析  

Clinical characteristics and treatment of two cases of syphilitic heart disease

作　　者：张晓荣[1] 陈文琦[1] 马小五[2] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)心脏超声科,江苏南京210006 [2]南京医科大学附属南京医院(南京市第一医院)皮肤科,江苏南京210006

出　　处：《中国医药导报》2015年第28期43-46,共4页China Medical Herald

基　　金：国家自然科学基金项目(81402619);江苏省科技发展计划项目(BK20130083);南京医科大学科技发展基金面上项目(2014NJMU033)

摘　　要：目的探讨梅毒性心脏病的临床特点及治疗。方法回顾性分析2014年3-9月南京医科大学附属南京医院心脏内科收治的2例伴有症状的梅毒性心脏病患者临床资料,并结合文献讨论分析。结果本组梅毒性心脏病中,男性患者为梅毒性冠状动脉口狭窄,女性患者为梅毒性主动脉关闭不全。结合病情程度不同,男性患者给予水剂青霉素治疗,女性给予长效青霉素治疗;2例患者治疗后临床症状均有明显改善。血清学随访3、6个月,两者梅毒螺旋体血清胶体凝集试验均为阳性,男性病例甲苯胺红试验（TRUST）阴性,女性病例TRUST为1∶1。结论影像学检查对梅毒性心脏病的早期诊断有积极的提示作用,青霉素治疗有效。Objective To investigate the clinical features and therapy of syphilitic heart disease. Methods Clinical data of 2 patients with syphilitic heart disease accompanied by symptoms from March to September 2014 in Nanjing First Hospital, Nanjing Medical University were retrospectively analyzed combined with literature. Results Among the 2 cas- es of syphilitic heart disease, the male patient was diagnosed with syphilitic coronary artery stenosis, and the female patient was diagnosed with syphilitic aortic regurgitation. The male patient was treated with aqueous penicillin and the female patient was treated with long-acting penicillin according the different severity of diseases. After treatment, clinical symptoms of two patients were significantly improved. Within 3 and 6 months for serological follow-up, their tre- ponema pallidum serum colloid agglutination test （TPPA） were positive; the toluidine red test （TRUST） of the male patient was negative and TRUST of the female patient was 1：1. Conclusion The imageological examination has a positive effect prompt on the early diagnosis of syphilitic heart disease, penicillin therapy is effective.

关 键 词：梅毒性心脏病 临床表现 诊断 治疗 

分 类 号：R377.1[医药卫生—病原生物学]