依达拉奉治疗中重度一氧化碳中毒后心肌损伤的效果  

Effect of Edaravone in the treatment of myocardial injury after moderate and severe carbon monoxide poisoning

作　　者：陈士轩 滕哈乐[2] 牛红霞[1] 褚晓雯[1] 黄金洪[2] 肖青[1] 夏于新[1] 韩颖[1] 

机构地区：[1]首都医科大学电力教学医院急诊科,北京100073 [2]首都医科大学电力教学医院心胸外科,北京100073

出　　处：《中国医药导报》2015年第28期112-115,共4页China Medical Herald

摘　　要：目的观察依达拉奉治疗中重度一氧化碳中毒后心肌损伤的效果。方法采用前瞻性研究方法,选择2009年10月-2014年12月就诊于首都医科大学电力教学医院急诊科,符合急性一氧化碳中毒诊断及分级标准的58例中重度患者,按照简单随机分组法分成观察组和对照组。对照组（27例）给予高压氧、甘露醇、醒脑静、能量合剂等常规治疗,观察组（28例）在常规治疗的基础上静脉滴注依达拉奉30 mg,2次/d,1周为1个疗程。比较治疗前及治疗1周后两组患者心肌肌钙蛋白（c Tn I）水平及心电图的变化。结果 1治疗前,两组患者心电图中心律失常、ST-T改变、Q-T间期延长发生率比较,差异均无统计学意义（P〉0.05）。治疗1周后,两组患者心电图中心律失常、ST-T改变、Q-T间期延长发生率均下降,与同组治疗前比较,差异均有统计学意义（P〈0.05）;且治疗后观察组心律失常、ST-T改变发生率明显低于对照组,两组比较差异有统计学意义（P〈0.05）。2治疗前,观察组和对照组c Tn I水平比较,差异无统计学意义（P〉0.05）。治疗1周后,观察组和对照组c Tn I水平均较同组治疗前下降,差异有统计学意义（P〈0.05）;且治疗后观察组c Tn I水平明显低于对照组,两组比较,差异有统计学意义（P〈0.05）。结论依达拉奉治疗中重度一氧化碳中毒后心肌损伤效果肯定,值得推广。Objective To observe the curative effect of Edaravone in the treatment of myocardial injury after moderate and severe carbon monoxide poisoning. Methods A prospective study was conducted. 58 eases of patients with moder- ate and severe carbon monoxide poisoning from October 2009 to December 2014 in Emergency Department of Electric Power Teaching Hospital of Capital Medical University were randomly divided into the observation group and the control group. The control group （27 eases） was treated with HBO, mannitol, Xingnaojing, energy mixture and other conventional treatment. The observation group （28 cases） on the basis of routine treatment, was treated with intravenous infusion of Edaravone 30 rag, twice a day, 1 week as 1 course. The changes of cardiac troponin （cTnI） and ECG in two groups before and after treatment were compared. Results ①Before treatment, the abnormal incidence of ECG in the arrhythmia, ST-T changes, Q-T interval prolongation were compared between the two groups, the differences were not statistically significant （P 〉 0.05）. After a week of treatment, the incidence of ECG in the arrhythmia, ST-T changes, Q-T interval prolongation all decreased, compared with before treatment, the differences were statistically significant （P 〈 0.05）. After treatment, the incidence of arrhythmia, ST-T changes in the observation group were significantly lower than those of the control group, the differences were statistically significant （P 〈 0.05）. ②Before treatment, the level of eTnI in the observation group and the control group had no statistically significant difference （P 〉 0.05）. After a week of treatment, the levels of cTnI all decreased than before treatment in the two groups, the differences were statistically significant （P 〈 0.05）. After treatment, the level of eTnI in the observation group was significantly lower than that of the control group, the difference was statistically significant （P 〈 0.05）. Conclusion The curative effect of Edaravone

关 键 词：中重度一氧化碳中毒 依达拉奉 心肌损伤 心电图 心肌肌钙蛋白 

分 类 号：R595.1[医药卫生—内科学]