不同剂量利拉鲁肽治疗肥胖型2型糖尿病的效果观察  

Effect observation of different doses of liraglutide in the treatment of obese type 2 diabetes mellitus

作　　者：章国仁 王爱华 方幼荣 江世亭 

机构地区：[1]江西省上饶市鄱阳县人民医院药剂科,江西鄱阳333100 [2]江西省上饶市鄱阳县人民医院护理部,江西鄱阳333100 [3]江西省上饶市鄱阳县人民医院内分泌科,江西鄱阳333100

出　　处：《中国当代医药》2015年第27期88-90,93,共4页China Modern Medicine

摘　　要：目的 探讨不同剂量利拉鲁肽治疗肥胖型2型糖尿病的临床疗效。方法 选取我院2013年5月~2015年5月收治的88例肥胖型2型糖尿病患者作为研究对象,按随机数字表法分为A、B两组（每组44例）,两组患者均应用利拉鲁肽进行治疗,A组的单次给药剂量为1.2 mg,B组为1.8 mg,比较两组患者的治疗效果。结果 两组患者治疗前的各项糖代谢、脂代谢、CRP及心血管指标比较,差异无统计学意义（P〉0.05）。治疗后,两组患者的FPG、2 hPG、BMI、TG、TC、LDL-C、CRP及各项心血管指标均较治疗前显著降低（P〈0.05）,组间比较差异无统计学意义（P〉0.05）。两组的一般低血糖及局部瘙痒、硬结发生率比较差异无统计学意义（P〉0.05）,A组的一过性腹泻、一过性胃肠道反应发生率均显著低于B组（P〈0.05）。结论 利拉鲁肽治疗肥胖型2型糖尿病具有良好的效果,单次给药剂量1.2 mg的治疗效果与1.8 mg相当,低剂量用药安全性更高。Objective To investigate the clinical efficacy of different doses of liraglutide treat with obese type 2 diabetes. Methods 88 patients with obesity type 2 diabetes from May 2013 to May 2015 in our hospital were divided into group A and group B by the random number table （n=44 eases）.All patients were treated with liraglutide,group A single dosage was 1.2 mg,group B was 1.8 mg,therapeutic effect between two groups was compared. Results The glucose metabolism,lipid metabolism,CRP and cardiovascular indicators of group A compared with group B were no significant difference （P〉0.05）.After treatment,the FPG,2 hPG,BMI,TG,TC,LDL-C,CRP and cardiovascular indices between two groups was significantly lower than before treatment respectively,with statistical differenc （P〈0.05）;General hypoglycemia,local itching and induration incidence between two groups was not statistically significant （P〉0.05）,but transient diarrhea,transient gastrointestinal reactions of group A were significantly lower than group B（P〈0.05）. Conclusion Liraglutide treatment of obesity type 2 diabetes has a good effect,a single dose of 1.2 mg can provide the same effect with 1.8 mg,but low doses of medication is more security.

关 键 词：肥胖型2型糖尿病 利拉鲁肽 给药剂量 

分 类 号：R977.15[医药卫生—药品]