糖尿病性黄斑水肿临床治疗进展  

Clinical treatment advances in diabetic macular edema

作　　者：夏风杰 闫峰[1] 陆燕[1] 黄振平[1] 

机构地区：[1]南京大学医学院临床学院,南京军区南京总医院眼科,江苏省南京市210002

出　　处：《眼科新进展》2015年第10期985-988,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81200719)~~

摘　　要：糖尿病性黄斑水肿(diabetic macular edema,DME)是糖尿病视网膜病变的一种,可导致视力下降。DME病理机制复杂,主要是由于血-视网膜屏障破坏,血管通透性增加所致。血管内皮生长因子(vascular endothelial growth factor,VEGF)、各种炎症介质和炎症因子共同参与了DME的病理发展过程。单纯抗VEGF治疗DME是不够的,还需联合抗炎治疗。尽管激光仍是目前治疗DME的主要方法,但激光治疗易造成视力损害。进一步探究抗VEGF药物、抗炎药物、激光光凝联合治疗DME的疗效,具有重要意义,可为DME治疗提供最佳方案,提高疗效,降低副作用。Diabetic macular edema （DME） is one serious complication of diabetic retinopathy, which can lead to visual loss. The pathophysiology of DME is complicated. It is mainly caused by the break of blood-retinal barrier and the leakage of retinal vessels. Vascular endothelial growth factors（VEGF） and other kinds of inflammation factors are also participated in the pathology of DME. Anti-VEGF treatments alone is not enough for the treatment of DME. Additional anti-inflammatory treatment is also essential to the treatment of DME. Although laser therapy is tile main treatment of DME, the destructive nature of laser therapy promote physicians to evaluate other treatment modali- ties. It is great significant to further detect the effect of combined treatment, which can provide a preferable treatment modality for DME.

关 键 词：糖尿病性黄斑水肿 血管内皮生长因子 抗炎治疗 激光治疗 

分 类 号：R587.2[医药卫生—内分泌]