北京市昌平区自然人群及糖尿病患者黄斑厚度调查及分析  

Investigation and analysis of macular thickness in natural population and diabetes patients in Changping district of Beijing

作　　者：曹曦[1,2] 信中[1,2] 袁明霞 谢荣荣[1,2] 冯建萍 杨金奎[1,2] 

机构地区：[1]首都医科大学附属北京同仁医院内分泌科 [2]糖尿病防治研究北京市重点实验室,北京100730

出　　处：《国际生物医学工程杂志》2015年第4期234-237,共4页International Journal of Biomedical Engineering

基　　金：北京市重大科技计划项目（D12110000412001）;临床流行病学北京市重点实验室2015开放课题（2015LCLB02）

摘　　要：目的利用光学相干断层扫描仪（0cT）测量并分析北京市昌平区自然人群黄斑厚度，并分析糖尿病患者是否存在黄斑厚度的增加。方法根据2011年“昌平区卫生与人群健康状况调查”，521例受试者（正常血糖233例，糖尿病前期174例，糖尿病114例）完成体格检查和血液生化指标的测定，包括空腹血糖、口服葡萄糖耐量试验（OGTT）。2h血糖和糖化血红蛋白（HbAlc），并通过OCT检查黄斑厚度。结果男性视网膜黄斑中心凹厚度（（246±22）μm）明显高于女性（（235±26）μm）（P〈0．001）。校正性别后，以年龄、HbAlc和身体质量指数（BMI）来划分的各组间黄斑厚度差异均无统计学意义（P〉0．05）。不同糖代谢状态的3组受试者黄斑中心凹、内环和外环厚度差异均无统计学意义（P〉0．05）。结论男性视网膜黄斑中心凹厚度显著高于女性；年龄、HbAlc和BMI与黄斑中心凹厚度无显著相关性；不同糖代谢状态受试者视网膜厚度问差异无统计学意义（p〉0．05）。Objective To measure the macular thickness of natural population in Changping district of Beijing by optical coherence tomography （OCT）, and to analyze whether there is an increased thickness in diabetic patients. Methods In a cross-sectional population-based study, OCT was performed on 521 subjects （233 with normal glucose homeostasis, 174 with pre-diabetes and 114 with type 2 diabetes （T2D） according to ＂2011 Health Examination Survey of Changping＂. The subjects also received physical examination and laboratory measurements including fasting plasma glucose （FPG）, oral glucose tolerance test （OGTF）-2 h plasma glucose and hemoglobin Ale （HbAlc）. Results The results showed that central subfield thickness （CST） of the retina of men （（246~22） p^m） was significantly greater than that of women （（235~26） p.m） （P〈0.001）. Meanwhile, no significant difference was found in the CST in subjects of different age, HbAlc and body mass index （BM1） （P~.05）. Difference in thickness of different glucose groups was not seen in central subfield, inner subfields and outer subfields（P〉0.05）. Conclusions Retina CST of men was significantly greater than that of women. No significant difference was found in the CST in subjects of different age, HbAlc and BMI.

关 键 词：糖尿病 黄斑 光学相干断层扫描 

分 类 号：R587.1[医药卫生—内分泌] R774.5[医药卫生—内科学]