参附注射液对感染性休克患者炎症反应及免疫功能影响的临床对照研究  

Effect of Shenfu Injection on Inflammatory Response and Immune Function in Patients with Septic Shock: a Randomized Controlled Study

作　　者：陈如杰[1] 张明[1] 潘利伟[1] 程碧环[1] 龚裕强[1] 金胜威[1] 应斌宇[1] 

机构地区：[1]温州医科大学附属第二医院重症医学科,浙江温州325027

出　　处：《中华中医药学刊》2015年第10期2461-2464,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：温州市科技局科研基金项目(Y20140256)

摘　　要：目的:探讨参附注射液对感染性休克患者炎症反应及免疫功能的影响。方法:将40例感染性休克患者随机分成参附治疗组20例、对照组20例,每组患者入院时均给予6 h的EGDT液体复苏方案治疗,同时选用合理的抗生素及基础治疗,分别检测治疗前和治疗后的第1、3、7天血清炎症指标肿瘤坏死因子(TNF-α)、白细胞介素1(IL-1)、C-反应蛋白(CRP)、血清降钙素原(PCT)及细胞免疫功能指标(CD3+、CD4+、CD8+、CD4+/CD8+)。记录治疗前后急性生理与慢性健康评分(APACHE II评分)和Marshall评分。结果:1治疗组与对照组间TNF-α、CRP、CD8+计数在治疗前后两组差别无显著性(P>0.05),而IL-1、PCT及CD3+、CD4+、CD4+/CD8+在治疗前及第1天两组差别无显著性(P>0.05),在第3、7天治疗组IL-1、PCT均低于对照组(P<0.05),(CD3+、CD4+、CD4+/CD8+)在第3、7天均高于对照组(P<0.05)。两组APACHE II评分和Marshall评分在治疗前,治疗后第1、3天差别无显著性(P>0.05),在第7天均低于对照组(P<0.05)。结论:参附注射液可降低感染性休克患者机体炎症反应及提高细胞免疫功能,缓解患者病情。Objective：To explore the effect of Shenfu Injection on inflammatory response and immune function in patients with septic shock. Methods ： A total of 40 patients with septic shock were randomized to 2 groups： Shenfn treatment group （n = 20） and control group（ n = 20）. Every patient received 6 h early goal directed therapy（EGDT） , antibiotics and other basic treatment. The levels of tumor necrosis factor - alpha（ TNF - α）, serum interleukin - 1 （ IL - 1 ）, C - reactive protein（CRP） ,procalcitonin（PCT） and CD3 ^＋ , CD4^＋ and CD8^ ＋ T cell were measured respectively and APACHE II score and Marshall score were recorded before treatment and on the 1st, 3rd and 7th day after treatment. Result：There was no difference of TNF -α, CRP, and CD8 ^＋ at every time point and IL- 1, PCT and. CD3 ^＋ , CD4^ ＋ and CD4 ^＋/CD8^＋ T cell counts at the time points before treatment and on the 1 st after treatment between two groups （P 〉 0.05）. The levels of IL - 1 and PCT were significantly lower and CD3^＋ , CD4^ ＋ and CD4^＋/CD8^＋ T cell counts were significantly higher in treatment group than those in control group at the 3rd and 7th day （P 〈 0.05 ）. APACHE II score and Marshall score had no difference in two groups before treatment and at the 1 st and 3rd day （P 〉 0.05 ）, but compared that on 7th day, the differences were statistically significant （P 〈 0.05）. Conclusion：Shenfu Injection can decrease body inflammatory response and increase body immune function in patients with septic shock .

关 键 词：参附注射液 感染性休克 炎症反应 免疫功能 

分 类 号：R441.9[医药卫生—诊断学]