稳定性冠心病患者心外膜脂肪组织与N端脑利钠肽前体水平的相关性研究  

Relationship between epicardial adipose tissue thickness and plasma Nterminal pro-B-type natriuretic peptide level in patients with stable coronary artery disease

作　　者：刘福成[1] 单光华[1] 边宁[1] 陈向辉[1] 蓝县武 张爱东[1] 

机构地区：[1]暨南大学附属第一医院心血管内科,广东广州510632

出　　处：《中国病理生理杂志》2015年第9期1617-1620,共4页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金博士启动项目(No.S2013040016081);暨南大学科研培育与创新基金资助项目(No.21612311)

摘　　要：目的:分析稳定性冠心病患者心外膜脂肪组织(EAT)厚度与血浆N端脑利钠肽前体(NT-pro BNP)水平的相关性。方法:115例因胸痛住院的患者行冠脉CTA并进一步行冠脉造影明确有无冠心病,选取冠脉CTA右心室游离壁切面测定EAT厚度。自动生化分析仪测定患者血浆NT-pro BNP水平。结果:81例患者确诊为稳定性冠心病,34例患者排除冠心病。2组患者左心室射血分数(LVEF)均正常。稳定性冠心病患者血浆NTpro BNP水平的自然对数[ln(NT-pro BNP)]明显高于无冠心病患者(P<0.05),EAT厚度明显高于无冠心病患者(P<0.05),两者之间呈正相关(P<0.05)。校正相关影响因素后,ln(NT-pro BNP)仍与EAT厚度呈正相关(P<0.05)。多因素回归分析显示,EAT厚度是ln(NT-pro BNP)的独立影响因素(P<0.05)。结论:稳定性冠心病患者EAT厚度和血浆NT-pro BNP水平均明显增加,两者密切相关。AIM：To analyze the relationship between epicardial adipose tissue （EAT） thickness and plasma N-terminal pro-B-type natriuretic peptide （ NT-proBNP ） level in the patients with stable coronary artery disease . METHODS：The patients with chest pain （ n=115） admitted to our hospital underwent coronary artery computer tomo-graphy and further underwent coronary angiography for confirming whether they had coronary artery disease .EAT thickness was evaluated at the right ventricular free wall imaged by coronary artery computer tomography .Plasma NT-proBNP level was examined by an automatic biochemistry analyzer .RESULTS：Eighty-one patients were confirmed to have stable coro-nary artery disease and thirty-four patients were excluded to have coronary artery disease .Left ventricular ejection fraction of these patients of 2 groups were all normal.The natural logarithm of plasma NT-proBNP level [ln（NT-proBNP）] of the patients with stable coronary artery disease was significantly higher than that of the patients without coronary artery disease （P〈0.05）.EAT thickness of the patients with stable coronary artery disease was also higher than that of the patients with -out coronary artery disease（P〈0.05）.EAT thickness was related to ln（NT-proBNP） positively （P〈0.05）.After adjust-ment of related impact factors , EAT thickness was still related to ln （NT-proBNP） positively （P〈0.05）.Multiple-factor regression analysis showed that EAT thickness was the independent influence factor on LnNT -proBNP （P〈0.05）.CON-CLUSION：EAT thickness and plasma NT-proBNP level are both increased significantly and is related to each other in the patients with stable coronary artery disease .

关 键 词：冠心病 心外膜脂肪组织 N端脑利钠肽前体 

分 类 号：R543.31[医药卫生—心血管疾病]