白陶土联合普萘洛尔对百草枯中毒小鼠肺组织毒物浓度的影响  

Effect of kaolin combined with propranolol on paraquat concentration in lungs of poisoned mice

作　　者：缪心军 朱秀华 陈玉熹 邱贤克 李勇 陈之力 章若斯 

机构地区：[1]浙江省温州市中心医院,浙江温州325000

出　　处：《上海预防医学》2015年第9期536-539,共4页Shanghai Journal of Preventive Medicine

基　　金：温州市2011年第二期科技计划项目(Y20110207)

摘　　要：[目的]观察白陶土联合普萘洛尔对百草枯(PQ)中毒小鼠肺组织毒物浓度的影响。[方法]144只ICR小鼠随机分为3组:PQ组、PQ+白陶土联合普萘洛尔组(下称治疗组)、对照组,PQ组、治疗组予PQ 100 mg/kg灌胃,治疗组在PQ灌胃后立即予白陶土48 g/kg联合普萘洛尔3.2 mg/kg灌胃,对照组给予等体积生理盐水灌胃,每组在造模后0.5、1、2、4、6、8、12、24 h时间点取小鼠肺组织进行病理检查,制作匀浆进行PQ浓度检测。[结果]PQ组小鼠肺组织出现肺泡毛细血管扩张,内皮细胞肿胀,小灶状或大片状炎性细胞浸润,以中性粒细胞为主,治疗组上述病变程度明显减轻。PQ组和治疗组小鼠灌胃0.5 h后肺组织PQ浓度明显上升,4 h达高峰;与PQ组相比,治疗组第4 h开始肺组织PQ浓度明显降低(P<0.05),持续至24 h。[结论]白陶土联合普萘洛尔可以降低PQ中毒小鼠肺组织毒物浓度,减轻肺部损伤,联合使用值得在临床上进一步研究。[ Objective ] To observe the effect of kaolin and propranolol on paraquat （PQ） concentration in the lungs of poisoned mice. [ Methods] A group of 144 ICR mice were randomly divided into 3 groups： PQ, treatment, and control. Then 100 mg/kg PQ were intragastrically administrated （ig） in PQ group and treatment group, while only the same volume normal saline was given in control group. And then 48 g/kg kaolin combined with 3.2 mg/kg propranolol wbre administered in treatment group immediately after poisoning while only the same volume of normal saline was given in the other two groups. Pathological examination was done and PQ concentration in lungs of the mice detected 0.5 h, I h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h after poisoning. [Results] In the lungs of the mice in PQ group occurred alveolar capillary expansion, endothelial cell swelling, small or large sheet-shaped inflammation cell infiltration and mainly neutrophils while in treatment group the above lesions were apparently alleviated. In PQ and treatment groups, PQ concentration in lungs of both groups rose significantly 0.5 h after poisoning and up to peak at 4 h. But PQ concentration in lungs decreased significantly in treatment group from 4 h to 24 h after poisoning （P 〈 0.05）, as compared with that in PQ group. [ Conclusion] PQ concentration in lungs of the poisoned mice was decreased and the injury alleviated when they were treated with kaolin combined with propranolol. It is held that further research is worth doing in clinical practice.

关 键 词：白陶土 普萘洛尔 百草枯中毒 肺组织 

分 类 号：R595.4[医药卫生—内科学]