糖尿病肾病与非糖尿肾病维持性血液透析患者桡动脉钙化情况及危险因素分析  

Radial artery calcification and its risk factors in maintenance hemodialysis patients with and without diabetic nephropathy

作　　者：陈圳炜[1] 曾海鸥[1] 罗敏虹[1] 袁丽萍[1] 马红梅[1] 伍强[1] 李强翔 杨铁城[1] 

机构地区：[1]广东省深圳市第四人民医院肾内科,深圳市518000 [2]湖南省中医药大学中西结合博士后流动站,长沙市410208

出　　处：《内科》2015年第5期601-603,642,共4页Internal Medicine

基　　金：中国博士后科学基金第53批面上资助(2013M531788);深圳市福田区卫生公益性科研项目(FTWS201312)

摘　　要：目的探讨糖尿病肾病(DN)与非糖尿肾病(NDN)维持性血液透析(MHD)患者桡动脉钙化(RAC)情况及其危险因素。方法选择维持性血液透析患者104例作为研究对象,其中DN患者30例(DN组),NDN患者74例(NDN组),比较分析两组患者一般情况、生化指标及RAC等的差异,探讨DN、NDN患者RAC情况及其危险因素。结果 104例MHD患者中发生RAC 20例,发生率为19.2%,DN组患者钙化发生率为46.7%(14/30),NDN组患者钙化发生率为8.1%(6/74)。DN组患者年龄、血肌酐、血管钙化情况与NDN组患者比较,差异有统计学意义(P<0.05)。多元线性逐步回归分析结果显示,糖尿病、中位透析龄≥60个月是MHD患者发生RAC的相对危险因素。结论在MHD患者中,DN患者的RAC发生率显著高于NDN患者,糖尿病、透析时间≥60个月是MHD患者发生RAC的相对危险因素。Objective To explore radial artery calcification（RAC） and its risk factors in maintenance hemodialysis （MHD） patients with and without diabetic nephropathy. Methods A total of 104 MHD patients were enrolled including 30 cases of DN （ DN group） and 74 cases of non-DN （NDN group）. General situation, biochemical parameters and RAC between the two groups were compared. Risk factors relating to RAC in the two groups were also explored. Results Of all the 104 MHD cases, there were 20 cases with RAC（19.2% ）. The incidences of RAC in DN group and NDN group were 46.7% （14/30） and 8.1% （6/74）, respectively. There were significant differences in age, serum creatinine, and RAC between two groups （P 〈 0.05 ）. Multiple linear stepwise regression analysis indicated that diabetics and duration of dialysis ≥ 60 months are the relative risk factors of RAC occurrence. Conclusions The MHD patients with DN have higher prevalence rate of RAC than those without DN. Diabetics and duration of dialysis≥60 months were the relative risk factors of RAC.

关 键 词：糖尿病肾病 血液透析 钙化 危险因素 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]