贝氏柯克斯体的分子致病机理研究进展  

Advances on molecular pathogenesis of Coxiella burnetii

作　　者：王涛[1] 宋立华[1] 

机构地区：[1]病原微生物生物安全国家重点实验室军事医学科学院微生物流行病研究所,北京100071

出　　处：《中国人兽共患病学报》2015年第9期876-880,885,共6页Chinese Journal of Zoonoses

摘　　要：贝氏柯克斯体(Coxiella burnetii,简写为Cb)是一类重要的人兽共患细胞内寄生菌,在家畜中广泛感染,感染人可导致不明发热—俗称Q热,或伴有肺炎、心内膜炎、肝炎、脊髓炎等。在我国Q热是一类被忽视的烈性传染病,误诊漏诊众多。需要警惕的是该病有突发爆发的可能。以荷兰为例,自2007至2010年,超过4 000荷兰人感染了Q热。近年来国外的Q热研究进展很快,特别是新出现的Cb无细胞培养和遗传学操作方法促进了Cb的致病机理研究,为研制新型实用的Q热防治策略提供了机遇。本文简要综述了Cb与宿主细胞间的相互作用机制,主要是脂多糖的免疫调节功能、囊泡发育机制及四型分泌系统的可能作用机理。Coxiella burnetii is an important zoonotic obligate intracellular pathogen, which can cause wide spread infections in domestic animals and human Q fever （unknown febrile illness） possibly accompanied by pneumonia, endocarditis, hepatitis, and osteomyelitis, etc. The recent Q fever outbreak in Netherlands raises the alert of Q fever outbreak in other areas. Basic re search on Q fever has progressed dramatically owing to the recently developed axenic culture and genetic manipulation of C. burnetii. This paper reviewed our current understanding of the interactions between C. burnetii and host cells in the aspects of immune modulation by LPS, formation and development of Coxiella containing vacuole, and possibly mechanisms of type IV secretion effectors.

关 键 词：Q热 贝氏柯克斯体 专性胞内寄生菌 人兽共患病 

分 类 号：R376[医药卫生—病原生物学]