复凝聚法制备滁菊挥发油微囊的工艺研究  

Study on the Technology of Preparing Microcapsules for Volatile Oil in Chrysanthemum by Complex Coacervation

作　　者：王盈盈[1] 时维静[1] 孙洁[1] 李响[1] 刘峰[1] 王茜[1] 

机构地区：[1]安徽科技学院食品药品学院,安徽凤阳233100

出　　处：《安徽科技学院学报》2015年第3期31-36,共6页Journal of Anhui Science and Technology University

基　　金：国家级大学生创新创业训练计划项目(AH201310879023);国家级大学生创新创业训练计划项目(201410879006);安徽科技学院第十二批大学生创新课题(15XSZ93;15XSZ95)

摘　　要：探索滁菊挥发油微囊的最佳制备工艺。采用复凝聚法制备滁菊挥发油微囊，以外观形态、粒径、包封率、载药量为指标，正交设计优选工艺条件。滁菊挥发油微囊的最佳制备工艺条件为：复合胶与挥发油的比例为1：1，温度为55℃，pH为4．O，固化剂量为1．5mL。制得的滁菊挥发油微囊形态呈圆形、光滑，粒径分布在80～120μm，平均包封率为（48．89±5．93）％，平均载药量为（13．11±2．30）％，TLC法显示供试品溶液与对照品溶液在相同的位置出现相同斑点。该制备方法操作简单易行，处方合理，制得微囊外观圆整，载药量和包封率较高。This paper is to study the preparation microcapsules of volatile oil trom Chrysanthemum montohum tla- mat. The microcapsules were prepared by complex coacervation with formulation, diameter, amount of the drug and encapsulation efficiency as evaluation index and the preparation was optimized by orthogonal experimental design. The best technology is that compound plastic and the volatile oil of the ratio is 1： 1, the temperature is 55 ℃, pH 4. 0 and formaldehyde in an amount of 1. 5 mL. the prepared microeapsules spherical with smooth surface, and the proportion with a diameter of 80 - 120p, m, encapsulation efficiency was （48.89 ± 5.93 ） %, and average drug loadings were （ 13.11 ± 2.30 ） %, TLC indication that the test solution and reference solution appeared at the same spot in the same location. The preparation process is simple and feasible, and the methods of evaluation are reliable. The microcapsules＇ appearance is round and normal. The drug loading and the encap- sulation efficiency are higher.

关 键 词：滁菊挥发油 复凝聚法 微囊 正交设计 

分 类 号：TQ460.6[化学工程—制药化工]