高血压靶器官损害患者高敏C反应蛋白和白细胞介素-6的变化及意义  

Changes of high sensitivity C-reactive protein and interleukin-6 in patients with hypertension and target organ damage and its significance

作　　者：邢金平[1] 来春林[1] 刘晓红[2] 赵建强[1] 齐杰[1] 胡凤云[3] 

机构地区：[1]山西省人民医院心内科,太原030012 [2]山西省人民医院特需病房,太原030012 [3]山西省人民医院神经内科,太原030012

出　　处：《中国药物与临床》2015年第9期1241-1243,共3页Chinese Remedies & Clinics

基　　金：山西省科技厅科技攻关项目(20120313018-8)

摘　　要：目的通过观察高血压靶器官损害患者血清高敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)变化,探讨其临床意义。方法分别检测健康对照组(100名)、单纯高血压组(100例)、高血压合并冠心病组(100例)、高血压伴脑梗死组(100例)患者hs-CRP和IL-6水平,进行对比分析。结果 4组年龄、性别构成比较,差异无统计学意义(P>0.05);高血压及靶器官损害组hs-CRP和IL-6水平与健康对照组相比差异有统计学意义(P<0.01),高血压合并冠心病组及高血压合并脑梗死组与高血压组比较差异有统计学意义(P<0.05)。结论 hs-CRP和IL-6水平增高,对预测高血压靶器官损害的病情和预后有重要意义。Objective To investigate the changes of high sensitivity C-reactive protein （hs-CRP） and inter-leukin-6 （IL-6） in patients with hypertension and target organs damage （TOD）, and to investigate its clinical signifi-cance. Methods The levels of hs-CRP and IL-6 in patients of the normal blood pressure group （n=100）, simple hy-pertension group （n=100）, hypertension and coronary heart disease group （n=100）, and hypertension and cerebral in-farction group （n=100） were measured, respectively. Results There were no statistically significant differences in the distribution of age and gender between the four groups （P〉0.05）. There were statistically significant differences in the expression levels of hs-CRP and IL-6 between the hypertension and TOD group and the normal control group （ P〈0.01）. Statistically significant differences were found between the hypertension group and the hypertension and coro-nary heart disease group or the hypertension and cerebral infarction group （ P〈0.05）. Conclusion The expression lev-els of hs-CRP and IL-6 increase in patients with hypertension and TOD, which has significance for the prediction and prognosis of hypertension and TOD.

关 键 词：高血压 冠状动脉疾病 脑梗塞 高敏C反应蛋白 白细胞介素6 

分 类 号：R544.1[医药卫生—心血管疾病]