4 p14区段rs6832151多态性与Graves病相关性研究  

Association of the rs6832151 within chromosomal band 4p14 with Graves′disease

作　　者：赵文娣[1] 孙卫华[1] 赵双霞[2] 宋怀东[2] 张晓梅[1] 

机构地区：[1] 蚌埠医学院第一附属医院内分泌科,233000 [2] 上海交通大学附属瑞金医院分子医学中心国家基因组学国家重点实验室

出　　处：《中华内分泌代谢杂志》2015年第9期787-790,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：用TaqMan 探针技术,在Fluidigm EPI 平台上对安徽蚌埠地区汉族617例Graves 病（GD）患者和4915名健康对照者4p14区段上rs6832151位点进行基因分型。结果显示,4p14区段rs6832151 G 与 Graves 病易感性有统计学意义（OR =1.39,P〈0.01）；且根据该位点基因分型构建的三种遗传模型（累加模型、显性模型、隐性模型）均具有显著统计学意义（均P〈0.01）；甲状腺肿大程度在该位点基因型亚组之间的差异无统计学意义（P〉0.05）。提示4p14上rs6832151的G 等位基因为蚌埠地区人群GD 的易感基因,显著增加GD 的发病风险。[Summary] The genotypes of rs6832151 in the 4p14 were genotyped by Taqman probe technique on FluidigmEPl platform in 617 patients with Graves′disease（ GD） and 4 915 health control subjects. The result showed thatRs6832151 Gin4p14wasstronglyassociatedwithGD（OR=1.39,P〈0.01）,withstatisticalsignificancefor three genetic models according to the locus genotyping （ additive model,dominant model,and recessive model,all P〈0.01）. There was no statistically significant difference in the sizes of goiter between the genotype subgroups（P〉0. 05）. The result suggests that rs6832151 G in 4p14 is the susceptibility genes of Graves′ disease in Bengbu population, and is related to the high risk of GD.

关 键 词：格雷夫斯病 4p14 Rs6832151 多态性 单核苷酸 

分 类 号：R581.1[医药卫生—内分泌]