抗器官排斥药物和方案对器官移植术后血脂变化的影响  

Effects of different anti-rejection drugs and projects on dyslipidemia after organ transplantation

作　　者：薛孟娟[1] 吕朝阳[1] 张尧[1] 何顺梅[1] 于明香[1] 

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032

出　　处：《中华内分泌代谢杂志》2015年第9期816-818,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：器官移植术后血脂异常是器官移植术后心血管疾病及移植物失功的重要危险因素之一。影响器官移植术后血脂变化的因素很多，然而随着器官移植的发展，不同年代影响术后血脂变化的因素也有所改变。本文综述了不同年代抗器官排斥药物包括环孢素、硫唑嘌呤、霉酚酸酯、他克莫司、雷帕霉素（西罗莫司）、激素以及单抗等免疫抑制剂应用的不同对术后受者血脂的影响。[Summary] Dyslipidemia after organ transplantation is one of the important risk factors of postoperative cardiovascular disease and graft dysfunction. There are many factors that result in postoperative dyslipidemia. However, the factors influencing serum lipid levels are changing with the development of organ transplantation. In this article the effects of different anti-rejection drugs such as cyclosporine, azathioprine, mycophenolate mofetil, tacrolimus, rapamycin （ sirolimus ） , corticosteroids, and monoclonal antibody on dyslipidemia after organ transplantation were summarized in different eras.

关 键 词：不同年代 器官移植 抗排斥药物 血脂异常 

分 类 号：R617[医药卫生—外科学]