羟丙基-β-环糊精与格列齐特包结作用的热力学研究  

Study on the Complexation Thermodynamics of the Hydroxypropyl-β-cyclodextrin with Gliclazide

作　　者：李潇[1] 洪海龙[1] 陈秋月[1] 米志南 

机构地区：[1]内蒙古工业大学,内蒙古呼和浩特010051

出　　处：《广州化工》2015年第18期58-59,共2页GuangZhou Chemical Industry

基　　金：内蒙古工业大学科学研究项目(X201308)

摘　　要：从热力学的观点出发,采用相溶解度法研究了不同温度下羟丙基-β-环糊精与格列齐特的包结作用,确定了包结过程的摩尔比和包结过程的稳定常数,进而对包结过程的热力学参数进行了计算,讨论了羟丙基-β-环糊精与格列齐特发生包结时的作用力。结果表明,羟丙基-β-环糊精与格列齐特可以按照1∶1的比例进行包结,且包结过程为放热反应,可以自发的进行。The thermodynamic parameters, molar ratio and stability constants of Gliclazide with hydroxypropyl-β-cyclodextrin were investigated by the phase solubility method at different temperatures. It was suggested that complexation should be formated in solution at 1∶1 molar ratio. The thermodynamic parameters obtained indicated that the complexation could proceed spontaneously along with the release of heat.

关 键 词：格列齐特 羟丙基-Β-环糊精 热力学性质 

分 类 号：R94[医药卫生—药剂学]