尿电导率在肾脏疾病中的变化及与胱抑素C的相关性研究  

Study on the changes of urine conductivity in common kidney diseases and the correlation between urine conductivity and cystatin C

作　　者：曹盛吉 姜凤全 万丽平[1] 李冰[1] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116011

出　　处：《国际检验医学杂志》2015年第19期2810-2811,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨电导率在肾脏疾病中的变化及其与血清胱抑素C(CysC)水平的相关性。方法该院住院患者723例,其中IgA肾病组81例,糖尿病肾病组104例,肾病综合征组130例,多发性骨髓瘤组89例,慢性肾小球肾炎组115例,肾结石组101例,慢性肾脏衰竭组103例。同期体检健康者205例纳入对照组。采用Sysmex公司生产的UF-1000i全自动尿沉渣分析仪测定尿电导率,日立7600全自动生化分析仪测定CysC,采用SPSS19.0软件比较各组指标,并对2项指标进行相关分析。结果各疾病组尿电导率均低于对照组,差异有统计学意义(P<0.05)。各疾病组尿电导率与CysC水平呈负相关(P<0.05)。结论电导率测定对反映肾脏疾病患者肾脏浓缩功能的变化及肾小球功能状况有一定的临床价值。Objective To investigate the changes of urine conductivity in common kidney diseases and the relationship between urine conductivity and cystatin C. Methods A total of 723 patients in the First Affiliated Hospital of Dalian Medical University were selected in this study and divided into IgA nephropathy group（ 81 patients）, diabetic nepbropathy group（104 patients）, ne pbritic syndrome group（ 130 patients）, multiple myeloma group（89 patients）, chronic glomerulonephritis group（ 115 patients）, renal calculus group（101 patients）and chronic renal failure group（103 patients）. Other 205 healthy persons were recruited into control group. The urine samples were analyzed by Sysmex automatic urinary sediment analyzer UF 1000i to determine the urine conductivity,while the serum samples were analyzed by Hitachi automatic biochemical analyzer 7600 to determine the cystatin C. All the re sults were statistically analyzed by SPSS19.0 software. Results The urine conductivity in kidney patients was significant lower than that of healthy people （P〈0. 05）. There was a significant negative correlation between urine conductivity and the cystatin C in the kidney patients（P〈0. 05）. Conclusion The urine conductivity might serve as an important index in evaluating the kidney func tion and urine concentration.

关 键 词：尿电导率 胱抑素C 肾脏疾病 

分 类 号：R692[医药卫生—泌尿科学]