健康成年人嗅球体积与年龄及嗅觉功能的相关性研究  

A correlation study on olfactory bulb volumes with ages and olfactory function in healthy adults

作　　者：杭伟[1] 刘钢[1] 韩彤[2] 张金玲[1] 张强[1] 

机构地区：[1]天津市环湖医院耳鼻咽喉头颈外科,300060 [2]天津市环湖医院放射科,300060

出　　处：《中华耳鼻咽喉头颈外科杂志》2015年第9期744-748,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：基金项目：天津市卫生局科技基金项目（09KY18、2014KZ040）;天津市卫生局攻关课题（12KG115）

摘　　要：目的 分析健康成年人嗅球体积与年龄及嗅觉功能的相关性.方法 选取100名身体健康的志愿者,男54名,女46名;年龄20 ～ 70岁,平均（42.6±4.8）岁,以10岁为一个年龄组,共分为5组.排除所有能引起嗅觉障碍的疾病,应用T＆amp;T嗅觉测试法检查所有受试者的嗅觉功能,行MRI检查,并对嗅球体积与年龄及嗅觉功能进行相关性分析.以SPSS 13.0软件对数据进行统计学分析.结果 男性左侧嗅球体积为（84.65 ±7.11）mm^3,右侧为（87.79±7.57） mm^3,平均嗅球体积为（86.14 ±7.37）mm^3;女性左侧嗅球体积为（69.58±4.72）mm^3,右侧为（71.43±5.29） mm^3,平均嗅球体积为（70.22±5.02） mm^3.男性左右两侧嗅球体积比较差异无统计学意义（t=1.024,P＞0.05）;女性左右两侧嗅球体积比较差异亦无统计学意义（t=0.987,P＞0.05）;男性左右两侧及平均嗅球体积与女性比较差异有统计学意义（t值分别为3.742、3.869、3.814,P值均＜0.01）.男性、女性平均嗅球体积与年龄分别呈负相关（r值分别为-0.588、-0.523,P值均＜0.01）.男性、女性平均嗅球体积与T＆amp;T嗅觉评分呈负相关（r值分别为-0.624、-0.587,P值均＜0.01）.结论 健康成年人左右两侧嗅球体积无差异;男性嗅球体积较女性明显增大;嗅球体积随年龄的增长而减小;嗅球体积随嗅觉功能的减退而减小.嗅球体积可以作为评价嗅觉功能的重要指标之一.Objective To analyze the correlation between olfactory bulb（OB） volumes and ages,as well as OB volumes and olfactory function in healthy adults.Methods One hundred healthy subjects,without any diseases which might cause smell dysfunction were selected to participate in this study.The ages of the subjects ranged from 20 to 70,with the mean age of 42.6 ± 4.8.These subjects were scaned for olfactory function by T＆amp;T testing,OB volumes assessed with Magnetic resonance imaging （MRI）.The correlation between OB volumes and ages as well as OB volumes and olfactory function in healthy adults was analyzed.SPSS 13.0 software was used to analyze the data.Results The left and right OB volumes of men were （84.65 ± 7.11） mm^3 and （87.79 ± 7.57） mm^3,average OB volume was （86.14 ± 7.37） mm^3.The left and right OB volumes of women were （69.58 ± 4.72） mm^3 and （71.43 ± 5.29） mm^3,average OB volume was （70.22 ± 5.02） mm^3.OB volume study revealed no statistical difference between the left and right OB volumes of men （t =1.024,P 〉0.05）.OB volume study revealed no statistical difference between the left and right OB volumes of women （t =0.987,P 〉 0.05）.OB volumes were lower in women as compared with men （t value were 3.742,3.869 and 3.814,all P 〈 0.01）.OB volumes were negatively correlated with ages in the subjects（r value were-0.588,-0.523,both P 〈 0.01）.Olfactory discriminate threshold was negatively correlated with OB volumes in the subjects （r value were-0.624,-0.587,both P 〈 0.01）.Conclusions This study revealed no statistical difference between the left and right OB volumes in healthy adults.OB volumes were lower in women as compared with men.As age went up,OB volume would become smaller.As olfactory function went down,OB volume would become smaller.OB volumes were expected to be a gauge of olfactory function.

关 键 词：嗅球 磁共振成像 嗅觉障碍 年龄因素 嗅觉 

分 类 号：R765[医药卫生—耳鼻咽喉科]