清藓饮治疗口腔扁平苔藓的临床疗效及免疫学作用机制研究  

Clinical and immunologic observation of Qingxianyin in the treatment of oral lichen planus

作　　者：杨续艳[1] 王晓琳 常亚娟[1] 李晓南[1] 

机构地区：[1]黑龙江中医药大学附属第一医院口腔科,哈尔滨150040 [2]大连市口腔医院

出　　处：《实用口腔医学杂志》2015年第5期707-709,共3页Journal of Practical Stomatology

基　　金：国家自然科学基金青年科学基金(编号:81403441);黑龙江中医药大学校基金项目(编号:201010);黑龙江省博士后项目(编号:LBH-Z11016)

摘　　要：目的:评价清藓饮治疗口腔扁平苔藓(OLP)的临床疗效,并探索其调节T细胞介导的免疫应答机制。方法:25例OLP患者服清藓饮,1剂/d,早、晚各1次,持续8周。空白对照组25例为健康志愿者,不服药。使用流式细胞术检测受试者外周血CD4+、CD8+淋巴细胞计数和百分比及CD4+/CD8+比值,观察评定"清藓饮"临床疗效。结果:患者经过8周的治疗后,显效18例,有效5例,无效2例,总有效率为92%。外周血中CD4+淋巴细胞计数及百分比上升(P<0.05),CD8+淋巴细胞计数和百分比下降,CD4+/CD8+比值上升(P<0.05)。治疗后各项指标均向对照组方向变化。结论:清藓饮治疗口腔扁平苔藓有明显的临床疗效,在促进黏膜愈合、改善微循环、提高细胞免疫功能方面具有明显作用。Objective：To evaluate of effects of Qingxianyin in the treatment of oral lichen planus（OLP）,and to explore its regula-tion of T lymphocytes cellular immune mechanism.Methods：25 cases of OLP were treated by Qingxianyin for 8 weeks and 25 heathy subjects were served as the blank controls.Before and after treatment,peripheral blood CD4 ＋,CD8 ＋ lymphocyte counts and percentages and CD4 ＋/CD8 ＋ ratio were measured by flow cytometry.The clinical effects of Qingxinayin were evaluated.Results：After 8 weeks of treatment,significant effect,improvement and ineffecacy were observed in 1 8,5 and 2 cases respectively.The total effective ratio was 92.0%.The CD4 ＋ lymphocyte counts and percentage increased（P 〈0.05）,CD8 ＋ counts and percentage de-creased（P 〈0.05）,CD4 ＋/CD8 ＋ ratio increased（P 〈0.05）.After treatment the indexes changed towards those of the healthy con-trols.Conclusion：Qingxianyin is effective in the treatment of OLP by promoting mucosal healing,microcirculation and improving im-mune function.

关 键 词：清藓饮 口腔扁平苔藓(OLP) T淋巴细胞 流式细胞术 

分 类 号：R276.8[医药卫生—中医五官科学]