An efficient synthesis of novel benzo[b]pyrido[3',2':4,5]thieno[2,3-e][1,6]naphthy-ridine-8-ones  

作　　者：Dao-Lin Wang Yong-Yang Wang Xiao-Ce Shi Jian Ma 

机构地区：[1]College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application of Functional Compound,Bohai University

出　　处：《Chinese Chemical Letters》2015年第9期1109-1112,共4页中国化学快报（英文版）

摘　　要：An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.

关 键 词：4-Bromomethylquinoline-2-one 3-Cyanopyridine-2-thione Benzo[b]pyrido[3＇ 2＇：4 5 ]thieno[23-e][1 6] naphthyridine-8-one Thorpe-Ziegler reaction Pictet-Spengler reaction 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]