Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates  

作　　者：Yi-Rou Jiang Fu-Hua Sun Xiao-Yong Zhou Wei-Bo Kong Xing-Yi Xie 

机构地区：[1]Department of Polymeric Biomaterials and Artificial Organs,College of Polymer Science and Engineering,Sichuan University

出　　处：《Chinese Chemical Letters》2015年第9期1121-1128,共8页中国化学快报（英文版）

基　　金：financially supported by the National Science Foundation of China(No.50973069);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(No.20101561-3-3)

摘　　要：A series of aminoalkyi phosphates（AAP-n,with carbon number n ranging from 2 to 6） are used as surface modifiers to prepare hydroxyapatite hydrocolloids.The resulting nanoparticles（Cn-HA） possess a coreshell structure where an ionized layer of calcium-（AAP-n） complex[^＋H3N-（CH2）n-OPO3Ca]encapsulates each hydroxyapatite core.Long-term colloidal stability is achieved due to the electrostatic repulsion among the suspending particles.The incorporation of AAP-n results in a preferential crystal growth along c-axis,showing an increasing aspect ratio of particles from C2-HA to C6-HA.Preliminary cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA particles.The functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials.A series of aminoalkyi phosphates（AAP-n,with carbon number n ranging from 2 to 6） are used as surface modifiers to prepare hydroxyapatite hydrocolloids.The resulting nanoparticles（Cn-HA） possess a coreshell structure where an ionized layer of calcium-（AAP-n） complex[^＋H3N-（CH2）n-OPO3Ca]encapsulates each hydroxyapatite core.Long-term colloidal stability is achieved due to the electrostatic repulsion among the suspending particles.The incorporation of AAP-n results in a preferential crystal growth along c-axis,showing an increasing aspect ratio of particles from C2-HA to C6-HA.Preliminary cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA particles.The functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials.

关 键 词：Hydroxyapatite Hydrocolloid Aminoalkyl phosphate Cytotoxicity 

分 类 号：R318.08[医药卫生—生物医学工程]