New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane  

作　　者：Guo-Ping Zeng Chang-Quan Cai Fen Tan Ming-Wu Ding 

机构地区：[1]Hubei Province Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients,Hubei University of Education [2]Key Laboratory of Pesticideε Chemical Biology of Ministry of Education,Central China Normal University

出　　处：《Chinese Chemical Letters》2015年第9期1158-1160,共3页中国化学快报（英文版）

基　　金：financial support of this work by the National Natural Science Foundation of China(No.21172085);the Natural Science Foundation of Hubei Province(No. 2014CFB567);the Open Foundation of Hubei Province Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients

摘　　要：A new efficient synthesis of 2,5,6-trisubstituted oxazolo（5,4-d]pyrimidi-7（6H）-ones by consecutive azaWittig reaction was developed.The sequential three-component reaction of oxazolyliminophosphorane4,isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7（6H）-ones 7 in good overall yields in the presence of catalytic amount of EtONa.A new efficient synthesis of 2,5,6-trisubstituted oxazolo（5,4-d]pyrimidi-7（6H）-ones by consecutive azaWittig reaction was developed.The sequential three-component reaction of oxazolyliminophosphorane4,isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7（6H）-ones 7 in good overall yields in the presence of catalytic amount of EtONa.

关 键 词：Oxazolo[5 4-d]pyrimidi-7（ 6H）-one Aza-Wittig reaction Iminophosphorane Carbodiimide 

分 类 号：O626[理学—有机化学]