Paradox of Using Intensive Lowering of Blood Glucose in Diabetics and Strategies to Overcome It and Decrease Cardiovascular Risks  

作　　者：衡先培 杨柳清 陈敏灵 李亮 黄苏萍 雷缨 

机构地区：[1]Department of Endocrinology,People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine [2]People's Hospital of Fujian Province [3]Academy of Integrative Medicine Fujian China [4]Fujian University of Traditional Chinese Medicine

出　　处：《Chinese Journal of Integrative Medicine》2015年第10期791-800,共10页中国结合医学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.81173179,81473550,81403329);Focal Point Project of Fujian Province in China(No.2012Y0037);Research Fund for Traditional Chinese Medicine Focus Lab of Fujian Provincial Department of Health(No.Wztn 201304);CHEN Keji Development Fund of Integrative Medicine(No.CKJ2009004);Special Fund for Key Subject of Fujian University of Traditional Chinese Medicine(No.X2014037)

摘　　要：Hyperglycemia significantly increases the risk of cardiovascular disease （CVD） in diabetics. However, it has been shown by a series of large scale international studies that intensive lowering of blood glucose levels not only has very limited benefits against cardiovascular problems in patients, but may even be harmful to patients at a high risk for CVD and/or poor long-term control of blood glucose levels. Therefore, Western medicine is faced with a paradox. One way to solve this may be administration of Chinese herbal medicines that not only regulate blood glucose, blood fat levels and blood pressure, but also act on multiple targets. These medicines can eliminate cytotoxicity of high glucose through anti-inflammatory and anti-oxidant methods, regulation of cytokines and multiple signaling molecules, and maintenance of cell vitality and the cell cycle, etc. This allows hyperglycemic conditions to exist in a healthy manner, which is called ＂harmless hyperglycemia＂ Furthermore, these cardiovascular benefits go beyond lowering blood glucose leve^s. The mechanisms of action not only avoid cardiovascular injury caused by intensive lowering of blood glucose levels, but also decrease the cardiovascular dangers posed by hyperglycemia.Hyperglycemia significantly increases the risk of cardiovascular disease （CVD） in diabetics. However, it has been shown by a series of large scale international studies that intensive lowering of blood glucose levels not only has very limited benefits against cardiovascular problems in patients, but may even be harmful to patients at a high risk for CVD and/or poor long-term control of blood glucose levels. Therefore, Western medicine is faced with a paradox. One way to solve this may be administration of Chinese herbal medicines that not only regulate blood glucose, blood fat levels and blood pressure, but also act on multiple targets. These medicines can eliminate cytotoxicity of high glucose through anti-inflammatory and anti-oxidant methods, regulation of cytokines and multiple signaling molecules, and maintenance of cell vitality and the cell cycle, etc. This allows hyperglycemic conditions to exist in a healthy manner, which is called ＂harmless hyperglycemia＂ Furthermore, these cardiovascular benefits go beyond lowering blood glucose leve^s. The mechanisms of action not only avoid cardiovascular injury caused by intensive lowering of blood glucose levels, but also decrease the cardiovascular dangers posed by hyperglycemia.

关 键 词：diabetes cardiovascular risk Chinese herbal medicine glucose toxicity harmless hyperglycemia 

分 类 号：R587.2[医药卫生—内分泌]