中国南海海绵Haliclona sp.中化学成分的研究  

Studies on chemical constituents from the South China Sea sponge Haliclona sp.

作　　者：许娇娇[1] 靳德军[2] 王佳[1] 祁菁[1] 赵川[3] 乔卫[1] 段宏泉[1,3] 唐生安[1] 

机构地区：[1]天津医科大学药学院,天津市临床药物关键技术重点实验室,天津300070 [2]海南医学院药学院,海口571199 [3]天津医科大学基础医学研究中心,天津300070

出　　处：《天津医科大学学报》2015年第5期385-387,共3页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(81102371);天津市自然科学基金资助项目(10JCYBJC15000)

摘　　要：目的:对采自中国广西涠洲岛海域海绵Haliclona sp.的化学成分进行分离和结构鉴定。方法:采用硅胶柱色谱、制备薄层色谱、凝胶柱色谱、半制备HPLC、重结晶等方法分离纯化,通过波谱方法分析,并对照文献来鉴定化合物的结构。结果:从海绵Haliclona sp.中分离的5个化合物,依次鉴定为孕甾烯醇酮(1),24-亚甲基胆甾醇(2),胆甾醇(3),苯丙酸(4),邻二苯甲酸丁酯(5)。结论:4,5为首次从该属海绵中分离得到的化合物。Objective： To study the chemical constituents from the South China Sea sponge Haliclona sp..Methods： The isolation and purification of the compounds were performed by column chromatography techniques with silica gel, PTLC, Toyopearl HW-40 and semi- preparative HPLC. Their structures were determined mainly by spectral data analysis and comparison with literatures. Results： Five compounds had been isolated and their structures were identified as pregnenolone （1）, 24-methylenecholesterol （2）, cholesterol （3）, phenylpropionic acid （4）, dibutylphthalat （5）. Conclusion： Compounds 4, 5 have been isolated for the first time from the genus Haliclona.

关 键 词：南海海绵 Haliclona sp. 化学成分 

分 类 号：R9[医药卫生—药学]