Multi-scale modeling of hemodynamics in the cardiovascular system  

作　　者：Hao Liu Fuyou Liang Jasmin Wong Takashi Fujiwara Wenjing Ye Ken-iti Tsubota Michiko Sugawara 

机构地区：[1]Graduate School of Engineering, Chiba University [2]Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC) [3]The Hong Kong University of Science and Technology(HKUST)

出　　处：《Acta Mechanica Sinica》2015年第4期446-464,共19页力学学报（英文版）

基　　金：supported by Grant-in-Aid for Scientifi Research(Grant(B)17300141);the Development and Use of the Next Generation Supercomputer Project of the MEXT,Japan;Fuyou Liang was supported by the National Natural Science Foundation of China(Grant 81370438);the SJTU Medical Engineering Cross-cutting Research Foundation(Grant YG2012MS24);Ken-iti Tsubota was partly funded by a Grant-in-Aid for Challenging Exploratory Research(Grant 25630046),JSPS;supporting the computing facilities essential for the completion of this study;Financial support provided by HKUST to JW is acknowledged

摘　　要：The human cardiovascular system is a closed- loop and complex vascular network with multi-scaled het- erogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale model- ing of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arter- ial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study： recent progress of patient-specific hemodynamic modeling in clinical applica- tions, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynarnic modeling.The human cardiovascular system is a closed- loop and complex vascular network with multi-scaled het- erogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale model- ing of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arter- ial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study： recent progress of patient-specific hemodynamic modeling in clinical applica- tions, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynarnic modeling.

关 键 词：Multi-scale modeling. Macro-hemodynamics.Micro-hemodynamics Cardiovascular system ENDOTHELIALCELL 

分 类 号：R54[医药卫生—心血管疾病]