缬沙坦联合胺碘酮对阵发性房颤患者NT-pro-BNP水平的影响  

The Influence of Valsartan Combined with Amiodarone on the NT-pro-BNP Level of Patients with Paroxysmal Atrial Fibrillation

作　　者：黄琦磊[1] 程显禄[1] 陈子国[1] 蒋凌[1] 王光友[1] 

机构地区：[1]福建医科大学附属南平第一医院

出　　处：《按摩与康复医学》2015年第17期16-17,共2页Chinese Manipulation and Rehabilitation Medicine

摘　　要：目的：观察缬沙坦联合胺碘酮治疗阵发性房颤（PAF）对患者N端脑钠素前体（NT-pro-BNP）水平的影响。方法：将133例阵发性房颤患者随机分为试验组（n=69）和对照组（n=64），均给予服用胺碘酮，试验组则配合服用缬沙坦（80mg/天），疗程为18个月；另选取60例健康体检者纳入正常组；采用电化学发光免疫法测定三组受试者的血浆NT-pro-BNP水平。结果：两组PAF患者其血浆NT-pro-BNP水平均显著高于正常组（P〈0.05）；治疗后，试验组血浆NT-pro-BNP水平显著低于对照组（P〈0.05）。结论：缬沙坦联合胺碘酮可更有效降低PAF患者的血浆NT-pro-BNP水平。Objective：To observe the influence of the treatment of valsartan combined with amiodarone on the NT-pro-BNP level of patients with par-oxysmal atrial fibrillation （PAF）. Methods：133 cases of patients with PAF were randomly divided into experimental group （n=69） and control group （n=64）, both groups treated by orally taking amiodarone, while experimental group combined with orally taking valsartan （80mg/d）, 18 months as a course of treatment;other 60 cases of healthy people were brought into normal group;used eletrochemiluminescence immunoassay to test the plasma NT-pro-BNP level of the three groups of subjects. Results：The plasma NT-pro-BNP level of the two groups of PAF patients were both significantly higher than that of normal group （P〈0.05）;after treatment, the plasma NT-pro-BNP level of experimental group was significantly lower than that of control group （P〈0.05）. Conclusion：The treatment of valsartan combined with amiodarone can effetively decease the plasma NT-pro-BNP level of PAF patients.

关 键 词：阵发性心房颤动 缬沙坦 胺碘酮 N端脑钠素前体 

分 类 号：R541.7[医药卫生—心血管疾病]