根除幽门螺杆菌对糖尿病血糖变异性的影响  

Effect of helicobacter pylori eradication on glucose variabitity in patients with diabetes mellitus

作　　者：胡家[1] 倪林[1] 姚林华[2] 张玲[1] 

机构地区：[1]湖州师范学院第一医院内分泌科,浙江湖州313000 [2]湖州师范学院第一医院消化内科,浙江湖州313000

出　　处：《中国现代医生》2015年第28期8-10,14,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2012KYB200);浙江省湖州市科技局项目(2012YSB15)

摘　　要：目的观察根除幽门螺杆菌对糖尿病胃轻瘫（DPG）患者血糖变异性的作用。方法选择2012年6月～2014年6月116例幽门螺杆菌阳性DGP患者随机分为两组，A组进行三联根除幽门螺杆菌治疗（埃索美拉唑＋呋喃唑酮＋左氧氟沙星），其中A组加用莫沙比利片。B组仅口服莫沙比利片，两组均进行72h动态血糖监测，比较两组间动态血糖指标，症状积分以及临床生化指标。结果治疗后，与B组比较，A组症状积分、最大血糖波动幅度（LAGE）、日内血糖平均波动幅度（MAGE）、餐后血糖波动幅度（MPPGE）、空腹血糖（FPG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—c）均降低，差异有统计学意义（P〈0．05）。结论根除幽门螺杆菌可明显改善幽门螺杆菌阳性糖尿病患者胃轻瘫症状，有利于改善血糖变异性。Objective To investigate the effect of eradication H.pylori treatment on glucose variabitity in patients with diabetic gastroparesis （DPG）. Methods A total of 116 patients infected with H.pylori who had diagnosed as DPG were included in the study from June 2012 to June 2014. They were randomly divided into two groups, Group A were given eradication H.pylori treatment （esomeprazole＋furazolidone＋levofloxacan）, in addition with Mosapride. Group B were only given Mosapride. Both groups underwent continuous glucose monitoring （CGM） for 72 h. The glucose variability, the symptom scores, biochemical findings were analyzed. Results After eradication H.pylori treatment, compared with group B, the symptom scores, the levels of largest amplitude of blood glucose excursion （LAGE）, mean amplitude of glyeemic excursion （MAGE）, postprandial glucose excursion （MPPGE）, fasting plasma glucose （FPG）, total cholesterol （TC）, low density lipoprotein （LDL-c） in the group A were decreased respectively（P〈0.05）. Conclusion H.pylori eradication can improve the DPG symptom, and also increase the therapeutic effect of the glucose variability.

关 键 词：幽门螺杆菌 糖尿病胃轻瘫 血糖变异性 

分 类 号：R587.1[医药卫生—内分泌]