子痫前期患者血浆ADMA与血清Hcy的相关性  

Correlation between plasma asymmetric dimethylarginine and serum homocysteine in patients with preeclampsia

作　　者：张建华[1] 赵欣媛[1] 张瑾[1] 

机构地区：[1]西安医学院第二附属医院,陕西西安710038

出　　处：《中国优生与遗传杂志》2015年第10期71-72,91,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨子痫前期患者血浆不对称性二甲基精氨酸(asymmetric dimethylarginine,ADMA)水平与同型半胱氨酸(homocysteine,Hcy)水平的相关性,以及ADMA、Hcy水平与子痫前期的关系。方法将93例子痫前期患者分为轻、重度两个亚组,同期正常的健康孕妇50例作为对照组。采用酶联免疫吸附法检测血浆ADMA浓度,化学发光免疫法检测血清Hcy浓度,比较组间血浆ADMA及血清Hcy水平,分析血浆ADMA与血清Hcy水平的相关性。结果轻、重度子痫前期组血浆ADMA水平均高于对照组,差异均有统计学意义(P<0.05;P<0.01);轻、重度子痫前期组血清Hcy水平均高于对照组,差异有统计学意义(均P<0.05)。Pearson相关分析显示,血浆ADMA水平与Hcy水平呈正相关(r=0.813,P<0.000)。线性逐步回归分析发现,血浆ADMA水平随血清Hcy水平的升高而增加,呈线性趋势(β=9.453,P<0.01)。结论子痫前期患者血浆ADMA、血清Hcy水平均升高,这二者的升高可能与子痫前期的发生、发展有关,ADMA、Hcy可能都是子痫前期的危险因素。Objective：To investigate the correlation between plasma asymmetric dimethylarginine and homocysteine of patients in preeclampsia. Methods：93 patients with preeclampsia were divided into two groups：mild and severe preeclampsia groups. At the corresponding period,there were 50 healthy pregnant women in control group. Plasma ADMA was detected by enzyme linked immunosorbent assay（ELISA）,and serum Hcy was detected by chemiluminescence immunoassay（CLIA）. Results：The levels of plasma ADMA in mild and severe preeclampsia groups were higher than those of control group（P0.05;P〈0.01）;The levels of serum Hcy in mild and severe preeclampsia groups were higher than those of control group（P〈0.05）. Pearson correlation analysis showed that plasma ADMA levels were positively correlated with serum Hcy levels（r=0.813,P〈0.000）.Linear regression analysis showed that plasma ADMA levels elevated with serum Hcy levels,with linear trend（β=9.453,P〈0.01）. Conclusion：Levels of plasma ADMA and serum Hcy are significantly increased in patients with preeclampsia,which is related with the occurrence and development of preeclampsia. Both of them may be risk factors of preeclampsia.

关 键 词：不对称性二甲基精氨酸 同型半胱氨酸 子痫前期 

分 类 号：R714.244[医药卫生—妇产科学]