右美托咪定对急性颅脑损伤开颅手术患者脑保护作用  

Protective Effects of Dexmedetomidine on Patients with Acute Craniocerebral Traum Craniotomy

作　　者：张铨[1] 吴俊山[1] 朱文涛[1] 陈明华[1] 

机构地区：[1]福建莆田市福州总医院第一附属医院麻醉科,莆田351100

出　　处：《中国医药导刊》2015年第9期951-952,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨右美托咪定对急性颅脑损伤开颅手术患者的脑保护作用。方法:选择68例急性颅脑损伤开颅手术患者,随机分为A组和B组各34例,全麻下行开颅手术,A组麻醉诱导前10min内缓慢静注右美托咪定1μg/kg,维持采用静脉连续输注0.5μg/kg·h至术毕,B组相同方式给予等量生理盐水。观察不同时点血清S-100β、NSE、IL-6、TNF-α水平及颅内压。结果:A组和B组T0-T3血清S-100β、NSE水平、血清IL-6、TNF-α水平呈上升趋势(P<0.05),A组T1-T3明显低于B组(P<0.05)。A、B组颅内压T1之后均显著下降(P<0.05),T3B组明显回升(P<0.05),且明显高于A组(P<0.05)。结论:右美托咪定可抑制急性颅脑损伤开颅手术患者炎症反应,具有一定的脑保护作用。Objective： To study the protective effect of dexmedetomidine in treatment of patients with acute craniocerebral traum craniotomy.Methods：68 patients with acute brain injury craniotomy surgery patients were randomly divided into group A and group B,34 patients under general anesthesia craniotomy,A group 10min intravenous dexmedetomidine given l gg/kg before induction of anesthesia After intravenous pump infusion of 0.5gg/kg·h to surgery, the same way as group B given normal saline.Observed four different time serum S-10013, NSE, 1L-6, TNF-α levels and intracranial pressure.Resuits：A group and group B T0-T3 serum S-10013,NSE level,serum IL-6,TNF-α level rise（P〈0.05）,A group T1-T3 serum S-100β,NSE,1L-6,TNF-α levels were significantly lower than in group B（P〈0.05）. After the group A and group B TI intracranial pressure were significantly decreased （P〈0.05）,T3B intracranial pressure group rebounded significantly（P〈0.05）,higher than group A（P〈0.05）.Conelusion：Dcxmcdetomidine suppressed patients with acute brain injury craniotomy inflammation,has a neuroprotective effect.

关 键 词：右美托咪定 颅脑损伤 炎症反应 颅内压 

分 类 号：R614[医药卫生—麻醉学]