布比卡因微球对大鼠局麻作用的药效学研究  

Local Anesthetic Effects of Bupivacaine Microspheres on Rats

作　　者：刘晓睿 张宜凡 

机构地区：[1]上海医药高等专科学校药学系,上海201318

出　　处：《中国医药导刊》2015年第9期953-954,956,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:研究布比卡因微球对大鼠的局麻作用。方法:取18只Wister大鼠随机分为生理盐水组、阳性对照组和微球组,分别注射生理盐水、0.75%盐酸布比卡因注射剂和布比卡因微球,通过热板实验考察药物对大鼠的局麻作用并进行分析。结果:布比卡因微球能显著延长大鼠运动与感觉阻滞的持续效应。结论:布比卡因微球对于大鼠的局部麻醉表现出明显缓释作用。Objective： To evaluate the local anesthetic effects of bupivacaine microspheres（BUP-MS） on rats.Mcthods：18 Wister rats were randomly divided into three groups and injected with saline, 0.75% bupivaeaine hydrochloride injection and BUP-MS respectively. The local anesthetic effects were investigated through rats＇ hot - plate test.Results：The action of BUP-MS could be prolonged for rats＇ sensory block and motor block significantly.Conclusion＇BUP-MS have significant sustainedrelease characteristics on rats.

关 键 词：布比卡因 微球 局麻药 缓释制剂 药效学 

分 类 号：R965[医药卫生—药理学]