血清内脂素水平与颈动脉粥样硬化的关系  

Relationship between serum visfatin level and carotid atherosclerosis

作　　者：葛继勇[1] 纪元[1] 王芳芳[1] 蒋建光[1] 曹海涛[1] 

机构地区：[1]常州市第二人民医院心血管内科,江苏省常州市213003

出　　处：《中国心血管病研究》2015年第9期836-838,共3页Chinese Journal of Cardiovascular Research

基　　金：常州市卫生局重大项目（项目编号：ZD201314）

摘　　要：目的 探讨血清内脂素水平与颈动脉粥样硬化的关系.方法 根据颈动脉超声结果将受试者分为无斑块组（638例）和斑块组（205例）,均检测血压、身高、体重、腰围、臀围、体质指数;采用酶联免疫吸附法检测血清内脂素水平;放射免疫法检测血清肿瘤坏死因子-α.结果 ①斑块组血清内脂素水平及肿瘤坏死因子-α均高于无斑块组（P＜0.01）.②Logistic回归分析显示,年龄、收缩压、低密度脂蛋白胆固醇、血清内脂素及肿瘤坏死因子-α均与颈动脉斑块独立相关（P＜0.05）.③受试者工作特征曲线（ROC曲线）显示,血清内脂素对颈动脉斑块形成的诊断准确性为0.838（P＜0.01）.结论 血清内脂素水平升高与颈动脉粥样硬化密切相关,并可作为颈动脉斑块形成的可靠评价指标.Objective To explore the relationship between serum visfatin level and carotid atherosclerosis. Methods Based on the results of carotid artery echocardiography, participants were divided into the group without carotid plaque （n=638） and group with carotid plaque （n=205）. Blood pressure, body height, body weight, waist and hip circumference, body mass index （BMI） were measured. Serum visfatin concentration was assessed by en- zyme immunoassay and TNF-ct was measured using radioimmunity kits. Results （1）The serum visfatin concentra- tion and TNF-a were significantly increased in the group with carotid plaque compared to group without carotid plaque （P〈0.01）. （2）Logistic regression indicated that age, systolic blood pressure, low density lipoprotein choles- terol, TNF-a and visfatin were all independently associated with the prevalence of carotid atherosclerosis （P〈 0.05 ）. （3）Receiver operating characteristic curve （ ROC ） revealed that the diagnostic accuracy of visfatin for carotid atherosclerosis was 0.838 （P〈0.01）. Conclusion Visfatin was significantly associated with carotid atherosclerosis and it was valuable to evaluate the formation of carotid plaque.

关 键 词：内脂素 颈动脉粥样硬化 诊断价值 

分 类 号：R543.4[医药卫生—心血管疾病]