SIRT5, functions in cellular metabolism with a multiple enzymatic activities  

作　　者：YANG Xin LIU BoYa ZHU WeiGuo LUO JianYuan 

机构地区：[1]Department of Medical Genetics, Peking University Health Science Center [2]Department of Biochemistry, Peking University Health Science Center [3]Department of Medical & Research Technology, School of Medicine, University of Maryland

出　　处：《Science China(Life Sciences)》2015年第9期912-914,共3页中国科学（生命科学英文版）

摘　　要：Mammalian Sirtuins are the homologs of yeast Saccharo myces cerevisiae Sir2 （silent information regulator 2） which functions in chromatin silencing to prevent genomi~ instability and aging by catalyzing the histone deacetyl ation [1]. There are seven members in Sirtuin famil, （SIRT1-SIRT7）. They all contain evolutionary conservel enzymatic domain which is nicotinamide adenine dinucleo tide （NAD）-dependent histone deacetylase that targets wide variety of histone or non-histone proteins for biologiq cal functions. Each of the Sirtuins has distinctive function~ / and cellular localization. SIRT1, 6 ＆ 7 are localized in nut cleus, and SIRT2 is localized at cytoplasm while SIRT3, ＆ 5 are localized in mitochondria [2]. ｜Mammalian Sirtuins are the homologs of yeast Saccharomyces cerevisiae Sir2(silen t information regulator 2),which functions in chromatin silencing to prevent genomic instability and aging by catalyzing the histone deacetylation[1].There are seven members in Sirtui n family(SIRT1-SIRT7).They all contain evolutionary conserved enzymatic domain which is nicotinamide adenine dinucleo-

关 键 词：组蛋白去乙酰化酶 细胞定位 代谢功能 非组蛋白 染色质沉默 酵母属 调节因子 SIR2 

分 类 号：Q25[生物学—细胞生物学]