New insights into autocrine cytokines produced by ischemic cardiomyocytes and ventricular remodeling  

作　　者：YU Xian LIAO YuHua 

机构地区：[1]Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology [2]Laboratory of Biological Targeted Therapy of the Ministry of Education

出　　处：《Science China(Life Sciences)》2015年第9期915-917,共3页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China(2007CB512000,2007CB512005)

摘　　要：Ischemic heart disease is one of the leading causes of death in the world. Although modern therapy of acute myocardial infarction （AMI） can reduce infarct size and result in an increased early survival rate, heart failure after AMI is still a major problem in survivors. Ventricular remodeling is critically important in heart failure after ischemia. It is characterized by changes in ventricular geometry and rigid- ity, as well as phenotypic modifications and functional changes of cardiomyocytes [1]. Induction of pro-inflam- matory cytokines was proved to be associated with the onset and progression of ventricular remodeling [2]. While the heart is not a traditional cytokine-producing organ, cyto- kines were found locally expressed within the myocardium after AM1 in rats [3]. Pro-inflammatory cytokines could activate nuclear factor nB （NF-KB）, a key transcriptional regulator of inflammation, which further induces cytokine production. This process forms an autocrine amplification loop. Modulation of the cytokines locally expressed in car- diomyocytes per se represents a possible new target for in- tervention in heart failure after AMI.Ischemic heart disease is one of the leading causes of death in the world.Although modern therapy of acute myocardial infarction(AMI)can reduce infarct size and result in an increased early survival rate,heart failure after AMI is still a major problem in survivors.Ventricular remodeling is critically important in heart failure after ischemia.It is characte-

关 键 词：炎性细胞因子 缺血性心脏病 心肌细胞 心室重构 自分泌 急性心肌梗死 心力衰竭 NF-κB 

分 类 号：R541[医药卫生—心血管疾病]