内皮祖细胞的研究现状及其在血管损伤治疗中的应用  

The Research Status of Endothelial Progenitor Cells and Its Application in the Treatment of Vascular Injury

作　　者：杨丽[1] 张颖超[1] 王晓博[1] 那仁格日勒[1] 

机构地区：[1]内蒙古大学生命科学学院,内蒙古呼和浩特010021

出　　处：《疾病监测与控制》2015年第9期636-637,共2页Journal of Diseases Monitor and Control

基　　金：2014年国家级大学生创新创业训练计划项目[201410126036]

摘　　要：内皮祖细胞是主要存在于脐血、外周血和骨髓中,可分化为内皮细胞的前体细胞。血管内皮损伤是很多心血管疾病的主要原因,内皮祖细胞可以作为内皮细胞的补充来源,用于治疗多种心血管疾病。近年来,这一领域的基础研究进展迅速,文章就内皮祖细胞的来源与分化、分离、培养与鉴定、血管生成期间的生物学特征及其治疗血管损伤的临床应用等方面的研究现状进行综述。Endothelial progenitor cells are precursor cells of endothelial cells which mainly found in umbilical cord blood, peripheral blood and bone marrow. Vascular endothelial injury is a major cause of many cardiovascular diseases. Endothelial progenitor cells can be used as a supplement source of endothelial cells for the treatment of various cardiovascular diseases. In recent years, the field of basic research progresses quickly. This paper expounds the current research status of EPCs in many ways, including source and differentiation, isolation, culture and identification, biological characteristics during angiogenesis and its clinical application for the treatment of vascular injury.

关 键 词：内皮祖细胞 表面标记物 动员及归巢 血管损伤治疗 

分 类 号：R541.9[医药卫生—心血管疾病]