水热体系中不同的前驱物对羟基磷灰石微结构的影响  

The effects of different calcium sources on the microstructure of hydroxyapatite in the hydrothermal system

作　　者：仇满德[1,2] 代爱梅[1,2] 杨盼[1,2] 李旭[1,2] 牛苗[1,2] 白国义[1,2] 

机构地区：[1]河北大学化学与环境科学学院,河北保定071002 [2]河北大学药物化学与分子诊断教育部重点实验室,河北保定071002

出　　处：《功能材料》2015年第19期19024-19027,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(10276732)

摘　　要：纳米羟基磷灰石由于具有良好的生物相容性和生物活性而应用广泛,形貌控制对其应用至关重要。本文以磷酸为磷源前驱物,利用XRD、SEM及EDS系统比较研究了水热体系中不同钙源前驱物对合成羟基磷灰石(HAP)晶体微结构及晶体生长的影响,同时利用配位体理论对其生长机理进行了初步探讨。研究结果表明,不同钙源前驱物在pH值=10,水热温度200℃、水热时间8h的条件下,均可以合成结晶度较好的纳米羟基磷灰石晶体,不同钙源前驱物对合成HAP产物的物相、分散性、结晶性及微结构有一定的影响,碳酸钙、氢氧化钙为钙源前驱物制备的HAP为类球状的纳米HAP,氯化钙、硝酸钙为钙源前驱物制备的HAP呈短棒状,但与以硝酸钙为钙源前驱物制备的HAP晶体的结晶度、规整度、均一性及晶体极性生长特性相比,氯化钙较差。EDS分析证实,不同的前驱物合成产物的HAP晶体不含有任何杂质,但HAP晶体的钙磷比略有差别,平均钙磷比约为1.75,合成的HAP属于富钙型的纳米羟基磷灰石。Hydroxyapatite(HAP)has been widely used because of its excellent biocompatibility and bioactivity,and the morphology control is of critical importance for its usage.In the present paper,using phosphoric acid as the P sources,nano-hydroxyapatite crystals were synthesized through hydrothermal method under the different Ca sources precursors.The effects of different Ca sources precursors on the microstructure and the growth of HAP crystals were studied by the X-ray diffraction(XRD),scanning election microscopy(SEM)and energy dispersive spectrometer(EDS),simultaneity,its growth mechanism was discussed using ligand theory.The results revealed that the better nano-HAP crystal could been synthesized at pH=10,temperature of 200 ℃,and time of 8hconditions.The dispersion,microstructure and crystallinity of HAP products were effected under the different Ca sources precursors,The near-spherical nano-HAP particles were synthesized by using CaCO3 and Ca(OH)2as the Ca sources respectively,CaCl2 and Ca(NO3)2as calcium source precursors,the nano-HAP crystal particles show morphology of short rod,especially,CaCl2 compare with Ca(NO3)2,It was obviously that the regularity dispersion,uniformity,crystallinity and polar growth characteristics of HAP was the best.In addition,EDS analysis results confirmed that the HAP products do not contain any impurity,the Ca/P ratio was difference at the different Ca sources precursors,the average Ca/P ratio was about 1.75,belonging to the rich calcium type of HAP.

关 键 词：不同前驱物 羟基磷灰石 晶体微结构 水热法 生长机理 

分 类 号：TQ074[化学工程]