人绒毛膜促性腺激素对解冻胚胎移植妊娠结局的影响  

Effect of human chorionic gonadotropin on thawed embryo transfer pregnancy outcome

作　　者：黄炜[1] 黄元华[1] 徐雯[1] 张毅[1] 谢宝国[1] 卢伟英[1] 

机构地区：[1]海南医学院附属医院生殖医学中心,海南海口570102

出　　处：《中国热带医学》2015年第9期1112-1115,共4页China Tropical Medicine

摘　　要：目的探讨人绒毛膜促性腺激素(Human chorionic gonadotropin,HCG)对解冻胚胎移植(FET)临床妊娠结局的影响。方法回顾性分析海南医学院附属医院生殖医学中心2011年1月至2014年4月4 503例解冻胚胎移植周期不孕症患者,根据胚胎移植后黄体期支持是否注射HCG分为HCG组和对照组,HCG组在移植胚胎后联合使用黄体酮和HCG,对照组在移植后单用黄体酮,对比分析两组患者临床妊娠结局。结果 HCG组和对照组的临床妊娠率分别为32.35%及34.86%,差异无统计学意义(P>0.05);HCG组的继续妊娠率低于对照组(57.32%和71.14%),差异无统计学意义(P>0.05)。结论解冻胚胎周期黄体支持治疗添加HCG对临床继续妊娠率没有显著的影响;患者年龄、临床治疗方案、不孕年限、ET次数、复苏率是影响继续妊娠的主要因素。Objective To investigate the effect of human chorionic gonadotropon（HCG）on clinical pregnancy outcomesof frozen embryo transfer（FET）. Methods The 4 503 FET cycles of infertility patients in the Reproductive Center ofAffiliated Hospital of Hainan Medical University from January 2011 to April 2014 was retrospectively analyzed. These patientswere divided into HCG group and control group based on HCG treatment or not in the luteal phase after embryo transplantation.Patients in HCG group were administrated with progesterone and HCG after embryo transfer, and cases in control group weregiven with progesterone only, then clinical pregnancy outcomes in two groups were compared. Results The clinicalpregnancy rate of HCG group and control group were 32.35% and 34.86%, there was no significant difference in two groups（P〉0.05）.The ongoing pregnancy rate of HCG group was lower than control group（57.32% and 71.14%）, but there was nodifference between two groups（P〉0.05）. Conclusion HCG treatment for FET cycles on luteal support showed no significqnteffect on the clinical outcomes. The age of patients, clinical treatment, duration of infertility, ET times and recovery rate wouldaffect the ongoing pregnancy rate.

关 键 词：绒毛膜促性腺激素 胚胎移植 黄体期支持 妊娠结局 

分 类 号：R714.13[医药卫生—妇产科学]